Shaping of monocyte and macrophage function by adenosine receptors.
TLDR
How adenosine affects the production of superoxide, nitric oxide, tumor necrosis factor-alpha, interleukin (IL)-12, IL-10, and vascular endothelial growth factor (VEGF) is delineated.About:
This article is published in Pharmacology & Therapeutics.The article was published on 2007-02-01 and is currently open access. It has received 215 citations till now. The article focuses on the topics: Purinergic signalling & Adenosine A2B receptor.read more
Citations
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Exploring the full spectrum of macrophage activation.
TL;DR: This Review suggests a new grouping of macrophages based on three different homeostatic activities — host defence, wound healing and immune regulation, and proposes that similarly to primary colours, these three basic macrophage populations can blend into various other 'shades' of activation.
Journal ArticleDOI
Macrophage plasticity, polarization, and function in health and disease.
Abbas Shapouri-Moghaddam,Saeed Mohammadian,Hossein Vazini,Mahdi Taghadosi,Seyed-Alireza Esmaeili,Fatemeh Mardani,Bita Seifi,Asadollah Mohammadi,Jalil Tavakol Afshari,Amirhossein Sahebkar +9 more
TL;DR: The protective and pathogenic role of the macrophage subsets in normal and pathological pregnancy, anti‐microbial defense, anti-tumor immunity, metabolic disease and obesity, asthma and allergy, atherosclerosis, fibrosis, wound healing, and autoimmunity are discussed.
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Adenosine receptors: therapeutic aspects for inflammatory and immune diseases
TL;DR: This work has generated excitement regarding the potential use of adenosine-receptor-based therapies in the treatment of infection, autoimmunity, ischaemia and degenerative diseases.
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Adenosine, an endogenous distress signal, modulates tissue damage and repair
TL;DR: It is argued that drugs targeting adenosine receptors might be useful adjuncts in many therapeutic approaches, usually having a cytoprotective function.
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Increased Level of Extracellular ATP at Tumor Sites: In Vivo Imaging with Plasma Membrane Luciferase
Patrizia Pellegatti,Lizzia Raffaghello,Giovanna Bianchi,Federica Piccardi,Vito Pistoia,Francesco Di Virgilio +5 more
TL;DR: The results show that ATP in the tumour interstitium is in the hundrends micromolar range, while it is basically undetectable in healthy tissues, so this approach offers a new tool for the investigation of the biochemical composition of tumour milieu and for development of novel therapies based on the modulation of extracellular purine-based signalling.
References
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Journal ArticleDOI
Innate Immune Recognition
TL;DR: Microbial recognition by Toll-like receptors helps to direct adaptive immune responses to antigens derived from microbial pathogens to distinguish infectious nonself from noninfectious self.
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Interleukin-10 and the interleukin-10 receptor.
TL;DR: Findings that have advanced the understanding of IL-10 and its receptor are highlighted, as well as its in vivo function in health and disease.
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Alternative activation of macrophages
TL;DR: The evidence in favour of alternative macrophage activation by the TH2-type cytokines interleukin-4 (IL-4) and IL-13 is assessed, and its limits and relevance to a range of immune and inflammatory conditions are defined.
Book ChapterDOI
Receptors for Purines and Pyrimidines
Vera Ralevic,Geoffrey Burnstock +1 more
TL;DR: In this review particular emphasis is placed on the discrepancy between the concentrations ofadenosine, ADP, and ATP in the purine receptors of UDP and UTP.
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Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.
TL;DR: The results indicate that IL-10 has important regulatory effects on immunological and inflammatory responses because of its capacity to downregulate class II MHC expression and to inhibit the production of proinflammatory cytokines by monocytes.