Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b
Jeong Kyu Kim,Ji Heon Noh,Kwang Hwa Jung,Jung Woo Eun,Hyun Jin Bae,Min Gyu Kim,Young Gyoon Chang,Qingyu Shen,Won Sang Park,Jung Young Lee,Jürgen Borlak,Suk Woo Nam +11 more
TLDR
It is shown that Sirtuin7 expression was up‐regulated in a large cohort of human hepatocellular carcinoma (HCC) patients and a regulatory loop is proposed whereby SIRT7 inhibits transcriptional activation of p21WAF1/Cip1 by way of repression of miR‐125a‐5p and miR-125b.About:
This article is published in Hepatology.The article was published on 2013-03-01 and is currently open access. It has received 281 citations till now. The article focuses on the topics: Ectopic expression & DNA methylation.read more
Citations
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Journal ArticleDOI
Sirtuins, a promising target in slowing down the ageing process
TL;DR: The involvement and usefulness of sirtuins in anti-ageing interventions are summarized and the potential role of curcumin in sIRT1-7 regulation is discussed, which is believed to be crucial for cell metabolism.
Journal ArticleDOI
Sorting out functions of sirtuins in cancer
Mendel Roth,WenYong Chen +1 more
TL;DR: The bifurcated roles of SIRT1, and perhaps several other sirtuins, in cancer may be in part a result of the nature of the genes that are involved in the cell’s genome maintenance systems.
Journal ArticleDOI
Activation of LncRNA TINCR by H3K27 acetylation promotes Trastuzumab resistance and epithelial-mesenchymal transition by targeting MicroRNA-125b in breast Cancer
TL;DR: TINCR could promote trastuzumab resistance and the accompanied EMT process in breast cancer and might be a potential indicator for prognosis and a therapeutic target to enhance the clinical efficacy of trastizumab treatment.
Book ChapterDOI
Hepatocellular carcinoma (HCC): Epidemiology, etiology and molecular classification.
TL;DR: This review examines the results of efforts in classifying HCC at the molecular, metabolic and immunologic levels and the ways they can be leveraged to develop targeted treatment options for HCC.
Journal ArticleDOI
Sirtuin regulation in aging and injury
Ninu Poulose,Raghavan Raju +1 more
TL;DR: An overview of studies on the role of sirtuins in aging and injury is provided and it is shown that aging is reported to be characterized by declining SIRT1 activity, and its increased expression or activation demonstrated prolonged life-span in lower forms of animals.
References
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Journal ArticleDOI
Global cancer statistics in the year 2000
TL;DR: The most common cancers in terms of new cases were lung (1.2 million), breast (1,05 million), colorectal (945 000), stomach (876'000), and liver (564'000).
Journal ArticleDOI
Sirtuins as regulators of metabolism and healthspan
TL;DR: The mammalian sirtuin protein family (comprising SIRT1–SIRT7) has received much attention for its regulatory role, mainly in metabolism and ageing, thereby acting as crucial regulators of the network that controls energy homeostasis and as such determines healthspan.
Journal ArticleDOI
The Sir2 Family of Protein Deacetylases
Gil Blander,Leonard Guarente +1 more
TL;DR: The role of NAD+, the unusual products of the deacetylation reaction, the Sir2 structure, and the Sir1 and Sir2 chemical inhibitors and activators that were recently identified are discussed.
Journal ArticleDOI
Targeting microRNAs in cancer: rationale, strategies and challenges.
TL;DR: The role of miRNAAs in tumorigenesis is described and the rationale, the strategies and the challenges for the therapeutic targeting of miRNAs in cancer are critically discussed.
Journal ArticleDOI
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins.
TL;DR: The notion that multiple human SIRT proteins have evolutionarily conserved and nonconserved functions at different cellular locations is supported and the lifespan of normal human cells, in contrast to that of lower eukaryotes, cannot be manipulated by increased expression of a single SIRT protein.
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