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Open AccessJournal ArticleDOI

Small but Perfectly Formed? Successes, Challenges, and Opportunities for Microfluidics in the Chemical and Biological Sciences

TLDR
The most successful applications of microfluidics over the last two decades are assessed and the areas where they had the greatest impact are highlighted.
About
This article is published in Chem.The article was published on 2017-02-09 and is currently open access. It has received 269 citations till now. The article focuses on the topics: Organ-on-a-chip & Microfluidics.

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Citations
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Point-of-care microfluidic devices for pathogen detection.

TL;DR: Next generation techniques relying on high sensitivity, specificity, lower consumption of precious reagents, suggest that rapid generation of results can be achieved via optical based detection of bacterial cells.
Journal ArticleDOI

A review on microreactors: Reactor fabrication, design, and cutting-edge applications

TL;DR: In this paper, a review of the latest trends and advancements in microstructured reactors is presented, focusing on the fabrication, commercial aspects, design principles, and cutting-edge applications of microreactors.
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Recent Advances in Droplet Microfluidics.

TL;DR: The rapid production (and analysis) of droplets allows for exceptionally high-throughput experimentation and data acquisition, and configurable channel designs, coupled with on-demand control architectures, engender a range of robust manipulations.
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Advances in healthcare wearable devices

TL;DR: Wearable devices have found numerous applications in healthcare ranging from physiological diseases such as cardiovascular diseases, hypertension and muscle disorders to neurocognitive disorders, such as Parkinson's disease, Alzheimer's disease and other psychological diseases as discussed by the authors.
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Microfluidics for sperm analysis and selection

TL;DR: Many burgeoning possibilities exist for engineers, biologists, and clinicians to improve current practices for infertility diagnosis and treatment, and the most promising avenues have the potential to improve medical practice.
References
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Journal ArticleDOI

Next-generation DNA sequencing.

TL;DR: Next-generation DNA sequencing has the potential to dramatically accelerate biological and biomedical research, by enabling the comprehensive analysis of genomes, transcriptomes and interactomes to become inexpensive, routine and widespread, rather than requiring significant production-scale efforts.
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Microfluidics: Fluid physics at the nanoliter scale

TL;DR: A review of the physics of small volumes (nanoliters) of fluids is presented, as parametrized by a series of dimensionless numbers expressing the relative importance of various physical phenomena as mentioned in this paper.
Journal ArticleDOI

Isolation of rare circulating tumour cells in cancer patients by microchip technology.

TL;DR: The CTC-chip successfully identified CTCs in the peripheral blood of patients with metastatic lung, prostate, pancreatic, breast and colon cancer in 115 of 116 samples, with a range of 5–1,281CTCs per ml and approximately 50% purity.
Journal ArticleDOI

Diagnostics for the Developing World: Microfluidic Paper-Based Analytical Devices

TL;DR: Microfluidic paper-based analytical devices are a new class of point-of-care diagnostic devices that are inexpensive, easy to use, and designed specifically for use in developing countries.
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