Some distorted thoughts about ketamine as a psychedelic and a novel hypothesis based on NMDA receptor-mediated synaptic plasticity.
Rachael Ingram,Heather Kang,Stafford L. Lightman,David E. Jane,Zuner A. Bortolotto,Graham L. Collingridge,David Lodge,Arturas Volianskis +7 more
TLDR
It is proposed that the psychedelic effects of ketamine may involve the inhibition of STP and, potentially, associated forms of working memory, which is a novel candidate mechanism for some effects ofketamine.About:
This article is published in Neuropharmacology.The article was published on 2018-06-06 and is currently open access. It has received 26 citations till now. The article focuses on the topics: Phencyclidine & NMDA receptor.read more
Citations
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Journal ArticleDOI
Psychedelics and Psychedelic-Assisted Psychotherapy
Collin M. Reiff,Elon E Richman,Charles B Nemeroff,Linda L. Carpenter,Alik S. Widge,Carolyn I. Rodriguez,Ned H Kalin,William M. McDonald +7 more
TL;DR: The research to support the use of LSD and ayahuasca in the treatment of psychiatric disorders is preliminary, although promising, and the database for MDMA and psilocybin is insufficient for FDA approval of any psychedelic compound for routine clinical use in psychiatric disorders.
Journal ArticleDOI
Ketamine and its metabolite, (2R,6R)-HNK, restore hippocampal LTP and long-term spatial memory in the Wistar-Kyoto rat model of depression.
TL;DR: The theory that ketamine may reverse the stress-induced loss of connectivity in key neural circuits by engaging synaptic plasticity processes to “reset the system” is supported.
Book
The Principles of Psychology
TL;DR: For instance, the authors discusses the multiplicity of the consciousness of self in the form of the stream of thought and the perception of space in the human brain, which is the basis for our work.
Journal ArticleDOI
The 1980s: d -AP5, LTP and a Decade of NMDA Receptor Discoveries
TL;DR: The purpose of this review is to recognize the important contributions made in the 1980s by Graham L. Collingridge and other key scientists to the advances in the authors' understanding of the functions of NMDA receptors throughout the central nervous system.
Journal ArticleDOI
Increasing doses of ketamine curtail antidepressant responses and suppress associated synaptic signaling pathways.
Ji-Woon Kim,Lisa M. Monteggia +1 more
TL;DR: Low dose ketamine produces antidepressant effects and has independent behavioral and synaptic effects compared to higher doses of ketamine that are used to model schizophrenia, which strengthen the knowledge on specific signaling associated with ketamine's rapid antidepressant effects.
References
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Book
The Principles of Psychology
TL;DR: For instance, the authors discusses the multiplicity of the consciousness of self in the form of the stream of thought and the perception of space in the human brain, which is the basis for our work.
Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal ArticleDOI
Cloned Glutamate Receptors
TL;DR: The application of molecular cloning technology to the study of the glutamate receptor system has led to an explosion of knowledge about the structure, expression, and function of this most important fast excitatory transmitter system in the mammalian brain.
Journal ArticleDOI
Magnesium gates glutamate-activated channels in mouse central neurones
TL;DR: The voltage dependence of the NMDA receptor-linked conductance appears to be a consequence of the voltage dependenceof the Mg2+ block and its interpretation does not require the implication of an intramembrane voltage-dependent ‘gate’.