Journal ArticleDOI
Specific in vitro and in vivo binding of 3H-raclopride a potent substituted benzamide drug with high affinity for dopamine D-2 receptors in the rat brain
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TLDR
The results suggest that 3H-raclopride labels dopamine D-2 receptors with high specificity in the rat brain both in vitro and in vivo, and thus, that it should be a useful tool in studies of central dopamine D -2 receptors.About:
This article is published in Biochemical Pharmacology.The article was published on 1985-07-01. It has received 500 citations till now. The article focuses on the topics: Raclopride & Dopamine receptor D1.read more
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D1 Dopamine Receptors in Prefrontal Cortex: Involvement in Working Memory
TL;DR: D1 dopamine receptors play a selective role in the mnemonic, predictive functions of the primate prefrontal cortex, and local injections of SCH23390 and SCH39166 induced errors and increased latency in performance on an oculomotor task that required memory-guided saccades.
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Imaging Synaptic Neurotransmission with in Vivo Binding Competition Techniques: A Critical Review
TL;DR: The results suggest that the changes in BP following changes in DA concentration might not be fully accounted by a simple occupancy model, and the data are reviewed supporting that agonist-mediated receptor internalization might play an important role in characterizing receptor-ligand interactions.
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Quantitative Analysis of D2 Dopamine Receptor Binding in the Living Human Brain by PET
TL;DR: Studies of [11C]raclopride binding indicate that clinically effective doses of chemically distinct neuroleptic drugs result in 85 to 90 percent occupancy of D2 dopamine receptors in the putamen of schizophrenic patients.
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Amphetamine-induced dopamine release in human ventral striatum correlates with euphoria
Wayne C. Drevets,Clara Gautier,Julie C. Price,David J. Kupfer,Paul E. Kinahan,Anthony A. Grace,Joseph L. Price,Chester A. Mathis +7 more
TL;DR: The preferential sensitivity of the ventral Striatum to the DA releasing effects of AMPH previously demonstrated in experimental animals extends to humans and the magnitude of ventral striatal DA release correlates positively with the hedonic response to AMPH.
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Central D2-Dopamine Receptor Occupancy in Schizophrenic Patients Treated With Antipsychotic Drugs
TL;DR: Clinical doses of all the currently used classes of antipsychotic drugs cause a substantial blockade of central D2-dopamine receptors in humans, and this effect appears to be selective for the antipsychotics.
References
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Journal ArticleDOI
Multiple receptors for dopamine.
John W. Kebabian,Donald B. Calne +1 more
TL;DR: Pharmacological and biochemical criteria can be used to separate those dopamine receptors which are linked to the enzyme adenylyl cyclase and those which are not.
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Opposing roles for D-1 and D-2 dopamine receptors in efflux of cyclic AMP from rat neostriatum.
J. C. Stoof,John W. Kebabian +1 more
TL;DR: It is shown here that stimulation of the D-2 receptor is followed by a reduction in cyclic AMP formation induced by V stimulation with D-1 agonists.
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Serotonergic component of neuroleptic receptors
TL;DR: It is suggested that serotonergic, as well as dopamine agonists or antagonists for rat frontal cortex and striatal receptors are involved in the mechanism of action of neuroleptic drugs.
Journal Article
A serotonergic component of neuroleptic receptors.
TL;DR: In this paper, a study of the relative binding affinities of a series of serotonin or dopamine agonists or antagonists for rat frontal cortex and striatal receptors was carried out, and significant correlations were obtained between the binding activities in the frontal cortex, and in vivo potencies in the pharmacological anti-tryptamine test.
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Quantitative analysis of drug-receptor interactions: I. Determination of kinetic and equilibrium properties.
TL;DR: Methods for direct determination of kinetic and equilibrium constants of simple bimolecular drug-receptor interactions are described as is the use of these measurements to verify the existence of a simple second order reaction.