Spinal Interneurons as Gatekeepers to Neuroplasticity after Injury or Disease.
Lyandysha V. Zholudeva,Victoria E. Abraira,Kajana Satkunendrarajah,Kajana Satkunendrarajah,Todd C. McDevitt,Todd C. McDevitt,Martyn Goulding,David S.K. Magnuson,Michael A. Lane +8 more
TLDR
In this paper, a review highlights the current understanding of spinal interneuron heterogeneity, their contribution to control and modulation of motor and sensory functions, and how this role might change after traumatic spinal cord injury.Abstract:
Spinal interneurons are important facilitators and modulators of motor, sensory, and autonomic functions in the intact CNS. This heterogeneous population of neurons is now widely appreciated to be a key component of plasticity and recovery. This review highlights our current understanding of spinal interneuron heterogeneity, their contribution to control and modulation of motor and sensory functions, and how this role might change after traumatic spinal cord injury. We also offer a perspective for how treatments can optimize the contribution of interneurons to functional improvement.read more
Citations
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The neurons that restore walking after paralysis
Claudia Kathe,Michael A. Skinnider,Thomas H. Hutson,Nicola Regazzi,Matthieu Gautier,Robin Demesmaeker,Salif Komi,Steven Ceto,Nicholas D. James,Newton Cho,Laetitia Baud,Katia Galan,Kaya J.E. Matson,Andreas Rowald,Kyungjin Kim,Ruijia Wang,Karen Minassian,John O. Prior,Leonie Asboth,Quentin Barraud,Stéphanie P. Lacour,Ariel J. Levine,Fabien Wagner,Jocelyne Bloch,Jordan W. Squair,Grégoire Courtine +25 more
TL;DR: In this paper , the authors show that spinal cord injury interrupts pathways from the brain and brainstem that project to the lumbar spinal cord, leading to paralysis, and they demonstrate that a single population of excitatory interneurons nested within intermediate laminae is essential for the recovery of walking with EES.
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Spinal Inhibitory Interneurons: Gatekeepers of Sensorimotor Pathways.
TL;DR: The spinal cord is both the initial entry site for peripheral information and the final output site for motor response, placing spinal circuits as paramount in mediating sensory responses and coordinating movement.
Journal ArticleDOI
Respiratory Training and Plasticity After Cervical Spinal Cord Injury.
Margo L Randelman,Lyandysha V. Zholudeva,Lyandysha V. Zholudeva,Stéphane Vinit,Michael A. Lane +4 more
TL;DR: In this paper, a review summarizes how non-invasive respiratory treatments can be used to harness this neuroplastic potential and enhance long-term recovery after spinal cord injuries. But, the authors focus on respiratory networks that are affected by cervical level SCI and do not consider the effect of training on non-respiratory networks.
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Transneuronal tracing to map connectivity in injured and transplanted spinal networks
Tara A. Fortino,Margo L Randelman,Adam Hall,Jasbir Singh,David M. Bloom,Esteban A. Engel,Daniel J. Hoh,Shaoping Hou,Lyandysha V. Zholudeva,Michael A. Lane +9 more
TL;DR: A review of advances in neuronal tracing using pseudorabies virus (PRV) and its use in the intact, injured, and transplanted spinal cord can be found in this article .
References
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Journal ArticleDOI
The Sensory Neurons of Touch
TL;DR: An integrative model in which ensembles of impulses arising from physiologically distinct LTMRs are integrated and processed in somatotopically aligned mechanosensory columns of the spinal cord dorsal horn underlies the nervous system's enormous capacity for perceiving the richness of the tactile world.
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The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats.
Florence M. Bareyre,Florence M. Bareyre,Martin Kerschensteiner,Martin Kerschensteiner,Olivier Raineteau,Thomas C. Mettenleiter,Oliver Weinmann,Martin E. Schwab +7 more
TL;DR: The anatomical basis of this recovery was investigated and it was found that after incomplete spinal cord injury in rats, transected hindlimb corticospinal tract axons sprouted into the cervical gray matter to contact short and long propriospinal neurons (PSNs).
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Dynamic Sensorimotor Interactions in Locomotion
TL;DR: Together these mechanisms contribute to the continuous dynamic adjustment of sensorimotor interactions, ensuring that the central program and feedback mechanisms are congruous during locomotion.