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Journal ArticleDOI

Staphylococcus aureus bacteremia: recurrence and the impact of antibiotic treatment in a prospective multicenter study.

TLDR
Nafcillin was superior to vancomycin in preventing bacteriologic failure (persistent bacteremia or relapse) for methicillin-susceptible S. aureus (MSSA) baiteremia following antistaphylococcal therapy, and most were relapses.
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This article is published in Medicine.The article was published on 2003-09-01. It has received 501 citations till now. The article focuses on the topics: Bacteremia & Vancomycin.

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Citations
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Journal ArticleDOI

Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management

TL;DR: This review comprehensively covers the epidemiology, pathophysiology, clinical manifestations, and management of S. aureus as a leading cause of bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device-related infections.
Journal ArticleDOI

Reduced Vancomycin Susceptibility in Staphylococcus aureus, Including Vancomycin-Intermediate and Heterogeneous Vancomycin-Intermediate Strains: Resistance Mechanisms, Laboratory Detection, and Clinical Implications

TL;DR: It is now becoming clear that sequential point mutations in key global regulatory genes contribute to the hVISA and VISA phenotypes, which are associated predominately with cell wall thickening and restricted vancomycin access to its site of activity in the division septum.
Journal ArticleDOI

Epidemiology of Methicillin-Resistant Staphylococcus aureus

TL;DR: The trends in both nosocomial and community-associated MRSA infections are examined and recent studies of the mechanisms that allow S. aureus to become resistant to currently available drugs are explored.
References
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Journal ArticleDOI

Reticuloendothelial System Phagocytic Activity in Cirrhosis and Its Relation to Bacterial Infections and Prognosis

TL;DR: It is suggested that decompensated cirrhotics with depressed reticuloendothelial system phagocytic activity are at great risk to acquire bacteremia, and that reticulendothetic activity has prognostic value in cirrhosis.
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Outcome of Staphylococcus aureus bacteremia according to compliance with recommendations of infectious diseases specialists: experience with 244 patients.

TL;DR: It is suggested that patient-specific management advice by infectious diseases consultants can improve the clinical outcome for patients with S. aureus bacteremia.
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Vancomycin for Staphylococcus aureus endocarditis in intravenous drug users.

TL;DR: Although vancomycin is used as an alternative to penicillinase-resistant penicillins for treatment of staphylococcal endocarditis, the findings raise the question of whether it is equivalent to these drugs in efficacy.
Journal ArticleDOI

A prospective multicenter study of Staphylococcus aureus bacteremia: incidence of endocarditis, risk factors for mortality, and clinical impact of methicillin resistance.

TL;DR: Persistent bacteremia (positive blood cultures at day 3 of appropriate therapy) was identified as an independent risk factor for both endocarditis and mortality, a unique observation not reported in other prospective studies of S. aureus baiteremia.
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Trimethoprim-Sulfamethoxazole Compared with Vancomycin for the Treatment of Staphylococcus aureus Infection

TL;DR: Vancomycin is superior to TMP-SMZ in efficacy and safety when treating intravenous drug users who have staphylococcal infections, however, all treatment failures occurred in patients with MSSA infection at any site.
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