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Journal ArticleDOI

Staphylococcus aureus bacteremia: recurrence and the impact of antibiotic treatment in a prospective multicenter study.

TLDR
Nafcillin was superior to vancomycin in preventing bacteriologic failure (persistent bacteremia or relapse) for methicillin-susceptible S. aureus (MSSA) baiteremia following antistaphylococcal therapy, and most were relapses.
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This article is published in Medicine.The article was published on 2003-09-01. It has received 501 citations till now. The article focuses on the topics: Bacteremia & Vancomycin.

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Citations
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Staphylococcus aureus Protein A Disrupts Immunity Mediated by Long-Lived Plasma Cells.

TL;DR: Failure to establish long-term protective Ab titers against S. aureus was not a consequence of diminished formation of B cell memory; instead, SpA reduced the proliferative capacity of PCs that entered the BM, diminishing the number of cells in the long-lived pool.
Journal ArticleDOI

Association of pharmacokinetic and pharmacodynamic aspects of linezolid with infection outcome.

TL;DR: Linezolid is the first antibiotic of a new class (oxazolidinones) that inhibits protein synthesis by binding to the bacterial 23S ribosomal RNA of the 50S subunit, thus blocking the formation of the functional 70S initiation complex, but it does not inhibit peptidyl transferase.
Journal ArticleDOI

Clinical and Microbiological Determinants of Outcome in Staphylococcus aureus Bacteraemia.

TL;DR: It is demonstrated that clinical rather than microbial factors are the major determinants of SAB outcome and underscores the importance of early treatment.
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Staphylococcus Aureus Pneumonia: A “Superbug” Infection in Community and Hospital Settings

TL;DR: Doctors should consider community-acquired Methicillin-resistant MRSA infections as possible emergencies with a high risk for organ system failure and shock, and empirical therapy should include vancomycin or linezolid.
References
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Journal ArticleDOI

Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing.

TL;DR: This research presents a novel, scalable and scalable approach that allows for real-time assessment of the severity of the infection and its impact on patients’ health.
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CDC definitions for nosocomial infections, 1988

TL;DR: The Centers for Disease Control (CDC) developed a new set of definitions for surveillance of nosocomial infections as mentioned in this paper, which combine specific clinical findings with results of laboratory and other tests that include recent advances in diagnostic technology.
Journal ArticleDOI

The APACHE III prognostic system. Risk prediction of hospital mortality for critically ill hospitalized adults.

TL;DR: The overall predictive accuracy of the first-day APACHE III equation was such that, within 24 h ofICU admission, 95 percent of ICU admissions could be given a risk estimate for hospital death that was within 3 percent of that actually observed.
Journal ArticleDOI

New criteria for diagnosis of infective endocarditis : Utilization of specific echocardiographic findings. Duke Endocarditis Service

TL;DR: Application of the proposed new criteria increases the number of definite diagnoses and should be useful for more accurate diagnosis and classification of patients with suspected endocarditis and provide better entry criteria for epidemiologic studies and clinical trials.
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