Journal ArticleDOI
Stimulation of LH fragments with reduced bioactivity following GnRH agonist administration in women.
D.R. Meldrum,Z. Tsao,S.E. Monroe,Glenn D. Braunstein,J. Sladek,J. K. H. Lu,W. Vale,J. Rivier,Howard L. Judd,R.J. Chang +9 more
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TLDR
Changes of BA LH appeared to be responsible for the suppression of ovarian androgen secretion during GnRH-a treatment and in turn may have contributed to the profound decreases of estrogen production by reducing the amount of precursor androgen available for aromatization.Abstract:
In eumenorrheic women with endometriosis and in oligo-amenorrheic women with polycystic ovarian disease (PCO), chronic administration of a long-acting GnRH agonist (GnRH-a) reduced the circulating concentrations of estrogens and androgens to levels similar to those of castrated women. The concommittant elevation of LH in both groups suggested that the measured immunoreactive LH had reducedbioactivity. In seven women with endometriosis, bioactive LH (BA LH) measured as the in-vitro secretion of testosterone by dispersed Leydig cells, was significantly (p < 0.001)reduced from 10.8 ± 1.2 (SEM) to 4.4 ± 0.2 mlU/ml at the end of 28 days of GnRH-a therapy. In five women with PCO, BA LH decreased from 44.2 ± 15.5 to 5.7 ± 0.6 mlU/ml(p = 0.06). These changes of BA LH appeared to be responsible for the suppression of ovarian androgen secretion during GnRH-a treatment and in turn may have contributed to the profound decreases of estrogen production by reducing the amount of precursor androgen available for aromatiz...read more
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Journal ArticleDOI
Suppression of Hyperandrogenism Does not Improve Peripheral or Hepatic Insulin Resistance in the Polycystic Ovary Syndrome
TL;DR: It is concluded that suppressing androgen levels into the normal range did not result in significant changes in insulin resistance in PCO, and controlling hyperandrogenemia is not a clinically effective modality to improve insulin action and thereby decrease the risk of noninsulin-dependent diabetes inPCO.
Journal ArticleDOI
Forty years of IVF
Craig Niederberger,Antonio Pellicer,Jacques Cohen,David K. Gardner,Gianpiero D. Palermo,C. O'Neill,S. Chow,Zev Rosenwaks,Ana Cobo,Jason E. Swain,William B. Schoolcraft,René Frydman,L.A. Bishop,Davora Aharon,Catherine M. Gordon,Erika New,Alan H. DeCherney,Seang Lin Tan,Richard J. Paulson,James M. Goldfarb,Mats Brännström,Jacques Donnez,Sherman J. Silber,Marie-Madeleine Dolmans,Marie-Madeleine Dolmans,Joe Leigh Simpson,Alan H. Handyside,Santiago Munné,Cristina Eguizabal,Nuria Montserrat,Juan Carlos Izpisua Belmonte,Alan O Trounson,Carlos Simón,Togas Tulandi,Linda C. Giudice,Robert J. Norman,Aaron J. W. Hsueh,Yingpu Sun,Neri Laufer,Ronit Kochman,Talia Eldar-Geva,Bruno Lunenfeld,Diego Ezcurra,Thomas D'Hooghe,Thomas D'Hooghe,Thomas D'Hooghe,Bart C.J.M. Fauser,Basil C. Tarlatzis,David R. Meldrum,Robert F. Casper,Human M. Fatemi,Paul Devroey,Daniela Galliano,Matts Wikland,Mark Sigman,Richard A. Schoor,Marc Goldstein,Larry I. Lipshultz,Peter N. Schlegel,Alayman Hussein,Robert D. Oates,Robert E. Brannigan,Heather E. Ross,Guido Pennings,Susan C. Klock,Simon Brown,Andre Van Steirteghem,Robert W. Rebar,Robert W. Rebar,Andrew R. LaBarbera,Andrew R. LaBarbera,Andrew R. LaBarbera +71 more
TL;DR: This monograph, written by the pioneers of IVF and reproductive medicine, celebrates the history, achievements, and medical advancements made over the last 40 years in this rapidly growing field.
Journal ArticleDOI
Progesterone levels on the day of human chorionic gonadotropin administration in cycles with gonadotropin-releasing hormone agonist suppression are not predictive of pregnancy outcome
Michael C. Edelstein,Howard Seltman,Beverly J. Cox,Shirley M. Robinson,Ruth A. Shaw,Suheil J. Muasher +5 more
TL;DR: In IVF cycles pretreated with GnRH-a, P levels on the day of hCG are not predictive of conceiving in that cycle, and no significant difference in clinical pregnancy rates or ongoing pregnancy rates occurred between the low and high P groups.
Journal ArticleDOI
Serum bioactive and immunoreactive luteinizing hormone and follicle-stimulating hormone levels in women with cycle abnormalities, with or without polycystic ovarian disease.
Bart C.J.M. Fauser,T. D. Pache,Steven W. J. Lamberts,Wim C. J. Hop,F. H. De Jong,Kristine D. Dahl +5 more
TL;DR: Serum steroid, gonadotropin, and alpha-subunit levels were assessed in 35 women with cycle abnormalities and 8 regularly cycling women in the early (cycle day 3 or 4) and mid ( cycle day 7 or 8) follicular phase of control cycles and non-PCOD patients.
Journal ArticleDOI
Routine pituitary suppression with leuprolide before ovarian stimulation for oocyte retrieval
David R. Meldrum,Arthur Wisot,Fredesminda Hamilton,Ana Lisa Gutlay,Wendy Kempton,David Huynh +5 more
TL;DR: Routine use of LA resulted in a highly efficient level of ongoing pregnancy per initiated cycle, and therefore may produce a superior first cycle for IVF-ET.