Strategies for Promoting Adherence to Antiretroviral Therapy: A Review of the Literature
TLDR
The literature on behavioral interventions to promote ART adherence is summarized and some of the most recent and innovative research on patient education and case management, modified directly observed therapy, contingency management, interventions emphasizing social support, and novel technologies to promote awareness are highlighted.Abstract:Â
The success of antiretroviral therapy (ART) for HIV infection, though widespread and resounding, has been limited by inadequate adherence to its unforgiving regimens, especially over the long term. This article summarizes the literature on behavioral interventions to promote ART adherence and highlights some of the most recent and innovative research on patient education and case management, modified directly observed therapy, contingency management, interventions emphasizing social support, and novel technologies to promote awareness. Research in the area of adherence in pediatric HIV infection and in resource-constrained international settings also is considered. Although adherence interventions have been successful in experimental trials, they may not be feasible or adaptable given the constraints of real-world clinics and community-based settings. Implementation and dissemination of adherence interventions needs increased attention as ART adherence research moves beyond its first decade. We conclude with suggestions for incorporating research findings into clinical practice.read more
Citations
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Journal ArticleDOI
Alcohol use and antiretroviral adherence: review and meta-analysis.
TL;DR: Results support a significant and reliable association of alcohol use and medication nonadherence and Methodological variables seem to moderate this association and could contribute to inconsistent findings across studies.
Journal ArticleDOI
Interventions to increase antiretroviral adherence in sub-Saharan Africa: a systematic review of evaluation studies
Till Bärnighausen,Krisda H. Chaiyachati,Krisda H. Chaiyachati,Natsayi Chimbindi,Ashleigh Peoples,Jessica E. Haberer,Marie-Louise Newell,Marie-Louise Newell +7 more
TL;DR: Evidence suggests that treatment supporters, directly observed therapy, mobile-phone text messages, diary cards, and food rations can effectively increase adherence in sub-Saharan Africa, but some interventions are unlikely to have large or lasting effects, and others are effective only in specific settings.
Journal ArticleDOI
Determinants of Adherence to Antiretroviral Therapy among HIV-Infected Patients in Africa.
Ayalu A. Reda,Sibhatu Biadgilign +1 more
TL;DR: Despite good adherence and program-related findings, antiretroviral treatment is challenged by a range of hierarchical and interrelated factors and there is substantial room for improvement of ART programs in sub-Sahara African countries.
Journal ArticleDOI
Cognitive Behavioral Therapy for Adherence and Depression (CBT-AD) in HIV-infected Injection Drug Users: A Randomized Controlled Trial
Steven A. Safren,Conall O'Cleirigh,Jacqueline R. Bullis,Michael Otto,Michael D. Stein,Mark H. Pollack +5 more
TL;DR: In patients managing multiple challenges including HIV, depression, substance dependence, and adherence, CBT-AD is a useful way to integrate treatment of depression with an adherence intervention and continued adherence counseling is likely needed to maintain or augment adherence gains in this population.
Journal ArticleDOI
Can money prevent the spread of HIV? A review of cash payments for HIV prevention
TL;DR: Cash transfer programs focused on changing risky sexual behaviors to reduce HIV risk suggest promise; ongoing RCTs with HIV incidence endpoints will shed more light on the efficacy of cash payments as strategy for HIV prevention.
References
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TL;DR: These Guidelines were developed by the Panel* on Clinical Practices for Treatment of HIV Infection convened by the Department of Health and Human Services and the Henry J. Kaiser Family Foundation.
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Edward J Mills,Jean B. Nachega,David R. Bangsberg,Sonal Singh,Beth Rachlis,Ping-ping Wu,Kumanan Wilson,Iain Buchan,Christopher J. Gill,Curtis Cooper +9 more
TL;DR: Important barriers to adherence are consistent across multiple settings and countries, and Clinicians should use this information to engage in open discussion with patients to promote adherence and identify barriers and facilitators within their own populations.
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Jane M. Simoni,Ann Kurth,Cynthia R. Pearson,David W. Pantalone,Joseph O. Merrill,Pamela A. Frick +5 more
TL;DR: It is concluded that even brief self-report measures of antiretroviral adherence can be robust, and recommend items and strategies for HIV research and clinical management.
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