Structural Insights into the Mechanisms and Pharmacology of K2P Potassium Channels.
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TLDR
The K2P (KCNK) channel class comprises an ion channel family that produces potassium leak currents that oppose excitation and stabilize the resting membrane potential in cells in the brain, cardiovascular system, immune system, and sensory organs.About:
This article is published in Journal of Molecular Biology.The article was published on 2021-04-20 and is currently open access. It has received 18 citations till now. The article focuses on the topics: Ion channel & Potassium channel.read more
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Alternative Targets for Modulators of Mitochondrial Potassium Channels
TL;DR: In this review, the various classes of mitochondrial potassium (mitoK) channels are presented and the chemical compounds that modulate their activity are described.
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Quaternary structure independent folding of voltage-gated ion channel pore domain subunits
TL;DR: In this article , crystal structures of a set of bacterial voltage-gated sodium channel (BacNaV) 'pore only' proteins reveal a surprising collection of non-canonical quaternary arrangements in which the PD tertiary structure is maintained.
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Structural Basis for pH-gating of the K+ channel TWIK1 at the selectivity filter
TL;DR: In this article , the authors present the structure of TWIK1 in lipid nanodiscs at high and low pH that reveal a previously undescribed gating mechanism at the K+ selectivity filter.
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Ion Channels: Intersection of Structure, Function, and Pharmacology.
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From Bench to Biomolecular Simulation: Phospholipid Modulation of Potassium Channels.
TL;DR: In this paper, the role of lipids in the regulation of K+ channels has been discussed, and atomic-level structures, along with experimental techniques and molecular simulations have helped guide our understanding of the importance of phospholipid interactions.
References
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A quantitative description of membrane current and its application to conduction and excitation in nerve
A. L. Hodgkin,A. F. Huxley +1 more
TL;DR: This article concludes a series of papers concerned with the flow of electric current through the surface membrane of a giant nerve fibre by putting them into mathematical form and showing that they will account for conduction and excitation in quantitative terms.
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The effect of sodium ions on the electrical activity of the giant axon of the squid
A. L. Hodgkin,B. Katz +1 more
Journal ArticleDOI
Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution.
TL;DR: Here it is shown how the K+ channel displaces water molecules around an ion at its extracellular entryway, and how it holds a K+ ion in a square antiprism of water molecules in a cavity near its intracellular entry way.
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Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter
Joshua M. Baughman,Fabiana Perocchi,Fabiana Perocchi,Hany S. Girgis,Hany S. Girgis,Molly Plovanich,Molly Plovanich,Casey A. Belcher-Timme,Casey A. Belcher-Timme,Yasemin Sancak,Yasemin Sancak,X. Robert Bao,X. Robert Bao,Laura Strittmatter,Laura Strittmatter,Olga Goldberger,Olga Goldberger,Roman L. Bogorad,Victor Koteliansky,Vamsi K. Mootha,Vamsi K. Mootha +20 more
TL;DR: Genome phylogenetic profiling, genome-wide RNA co-expression analysis and organelle-wide protein coexpression analysis are used to predict proteins functionally related to MICU1, establishing MCU as an essential component of the mitochondrial Ca2+ uniporter.
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The mitochondrial calcium uniporter is a highly selective ion channel
TL;DR: By patch-clamping the inner mitochondrial membrane, it is concluded that the properties of the current mediated by this novel channel are those of the MCU, enabling high Ca2+ selectivity despite relatively low cytoplasmic Ca 2+ concentrations.