Journal ArticleDOI
Structure, function and pathophysiology of protease activated receptors.
Mark N. Adams,Rithwik Ramachandran,Mei-Kwan Yau,Jacky Y. Suen,David P. Fairlie,Morley D. Hollenberg,John D. Hooper +6 more
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TLDR
This review examines common and distinguishing structural features of PARs, mechanisms of receptor activation, trafficking and signal termination, and discusses the physiological and pathological roles of these receptors and emerging approaches for modulating PAR-mediated signaling in disease.About:
This article is published in Pharmacology & Therapeutics.The article was published on 2011-06-01. It has received 331 citations till now. The article focuses on the topics: G protein-coupled receptor & Protease-activated receptor.read more
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Proteinase-activated receptors
TL;DR: The role of thrombin in such processes as wound healing and the evidence implicating PAR-1 in vascular disorders and cancer are described and advances in the understanding ofPAR-1-mediated intracellular signaling and receptor desensitization are identified.
Journal ArticleDOI
Endothelial cell control of thrombosis.
TL;DR: A greater understanding into the role of the endothelium can provide new avenues for exploration and novel therapies for the management of thromboembolisms.
Journal ArticleDOI
Orchestrating house dust mite-associated allergy in the lung
Lisa G. Gregory,Clare M. Lloyd +1 more
TL;DR: This work reviews the myriad ways in which HDM allergic responses are orchestrated and describes the molecular pathways that elicit HDM-associated pathology, likely to reveal novel targets for therapeutic intervention.
Journal ArticleDOI
Thromboinflammation: challenges of therapeutically targeting coagulation and other host defense mechanisms
Shaun P. Jackson,Shaun P. Jackson,Shaun P. Jackson,Roxane Darbousset,Roxane Darbousset,Simone M. Schoenwaelder,Simone M. Schoenwaelder +6 more
TL;DR: The role of basic aspects of coagulation and α-thrombin in promoting thromboinflammatory responses is focused on and insights gained from clinical trials on the effects of various inhibitors ofCoagulation on thrombosis with associated inflammation are discussed.
Journal ArticleDOI
Neural tube closure: cellular, molecular and biomechanical mechanisms.
TL;DR: The cellular, molecular and biomechanical mechanisms involved in neural tube closure are reviewed, based on studies of various vertebrate species, focusing on the most recent advances in the field.
References
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Journal ArticleDOI
Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation.
TL;DR: A novel signaling mechanism in which thrombin cleaves its receptor's amino-terminal extension to create a new receptor amino terminus that functions as a tethered ligand and activates the receptor is revealed.
Journal ArticleDOI
Thrombin signalling and protease-activated receptors
TL;DR: Roles for PARs are beginning to emerge in haemostasis and thrombosis, inflammation, and perhaps even blood vessel development.
Journal ArticleDOI
In vitro: Response of plant growth regulators and antimalformins on conidia germination of Fusarium mangiferae and incidence of mango malformation
TL;DR: The present findings do not authenticate the involvement of F. mangiferae in the disease, however hormonal imbalance, most probably ethylene, might be responsible for deformed functional morphology of panicle and a signal transduction mechanism of stress-stimulated ethylene imbalance causing physio-morphological changes in reproductive organs of mango flower and thereby failure of fertilization and fruit set needs to be investigated.
Journal ArticleDOI
NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control
TL;DR: Comment intervient le NF-kB, quels sont les systemes dans lesquels il joue un role, tels que les messages intracellulaires, l'activation des cellules C, the regulation of the cytokinine, ou encore l'utilisation par les virus
Journal Article
Proteinase-Activated Receptors
TL;DR: The role of thrombin in such processes as wound healing and the evidence implicating PAR-1 in vascular disorders and cancer are described and advances in the understanding ofPAR-1-mediated intracellular signaling and receptor desensitization are identified.