Journal ArticleDOI
Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing.
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TLDR
6 additional isoforms of the NMDA receptor generated via alternative splicing by molecular analysis of cDNA clones isolated from a rat forebrain cDNA library are reported, indicating that theNMDA receptor consists of heterogeneous molecules that differ in the extracellular sequence of the amino- and carboxyl-terminal regions.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1992-06-30. It has received 548 citations till now. The article focuses on the topics: Alternative splicing & Peptide sequence.read more
Citations
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Molecular diversity of glutamate receptors and implications for brain function.
TL;DR: The molecular and functional diversity of the glutamate receptors is reviewed and their implications for integrative brain function are discussed.
Journal ArticleDOI
Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95
TL;DR: The yeast two-hybrid system was used to show that the cytoplasmic tails of NMDA receptor subunits interact with a prominent postsynaptic density protein PSD-95, which may affect the plasticity of excitatory synapses.
Journal ArticleDOI
NMDA receptor subunits: Diversity, development and disease
TL;DR: Biophysical, pharmacological and molecular methods have been used to determine the key features conferred by the various NMDAR subunits, and have helped to establish which NMD AR subtypes are present at particular synapses.
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Changing subunit composition of heteromeric NMDA receptors during development of rat cortex
TL;DR: Direct evidence is presented that NMDA receptors exist in rat neocortex as heteromeric complexes of considerable heterogeneity, some containing both NR2A and NR2B subunits.
Journal ArticleDOI
Glutamate receptors in the mammalian central nervous system
TL;DR: Recent progress in the research for GluRs is reviewed with special emphasis on the molecular diversity of the GluR system and its implications for physiology and pathology of the CNS.
References
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Journal ArticleDOI
The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous System
TL;DR: 'The following abbreviations have been used in the text'; I3-N-uxalyl-L-a,l3diaminu-prupiunic acid; ACPD, Trans-l-aminu-cydupentyl-I,3-dicarbuxylate; AMPA, a aminU-3-hydruxy-5-methyl-isoxazole-4-propionate; AP4, 2-
Journal ArticleDOI
Excitatory amino acid neurotoxicity and neurodegenerative disease
Brian S. Meldrum,John Garthwaite +1 more
TL;DR: In vivo and in vitro studies of the cytotoxicity of amino acids are reviewed and the contribution of such toxicity to acute and chronic neurodegenerative disorders is summarized.
Journal ArticleDOI
Molecular cloning and characterization of the rat NMDA receptor
Koki Moriyoshi,Masayuki Masu,Takahiro Ishii,Ryuichi Shigemoto,Noboru Mizuno,Shigetada Nakanishi +5 more
TL;DR: A complementary DNA encoding the rat NMDA receptor has been cloned and characterized and it has been found that this protein has a significant sequence similarity to the AMPA/kainate receptors.
Journal ArticleDOI
A family of AMPA-selective glutamate receptors
Kari Keinänen,William Wisden,Bernd Sommer,Pia Werner,Anne Herb,Todd A. Verdoorn,Bert Sakmann,Peter H. Seeburg +7 more
TL;DR: Four cloned cDNAs encoding 900-amino acid putative glutamate receptors with approximately 70 percent sequence identity were isolated from a rat brain cDNA library and in situ hybridization revealed differential expression patterns of the cognate mRNAs throughout the brain.
Journal ArticleDOI
Synthesis and processing of asparagine-linked oligosaccharides.
S C Hubbard,R J Ivatt +1 more