Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons.
TLDR
The combination of regulated addition and continuous replacement of synaptic receptors can stabilize long-term changes in synaptic efficacy and may serve as a general model for how surface receptor number is established and maintained.About:
This article is published in Cell.The article was published on 2001-05-04 and is currently open access. It has received 1106 citations till now. The article focuses on the topics: Metaplasticity & Silent synapse.read more
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LTP and LTD: an embarrassment of riches.
Robert C. Malenka,Mark F. Bear +1 more
TL;DR: This work reviews those forms of LTP and LTD for which mechanisms have been most firmly established and examples are provided that show how these mechanisms can contribute to experience-dependent modifications of brain function.
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Glutamate Receptor Ion Channels: Structure, Regulation, and Function
Stephen F. Traynelis,Lonnie P. Wollmuth,Chris J. McBain,Frank S. Menniti,Katie M. Vance,Kevin K. Ogden,Kasper B. Hansen,Hongjie Yuan,Scott J. Myers,Raymond Dingledine +9 more
TL;DR: This review discusses International Union of Basic and Clinical Pharmacology glutamate receptor nomenclature, structure, assembly, accessory subunits, interacting proteins, gene expression and translation, post-translational modifications, agonist and antagonist pharmacology, allosteric modulation, mechanisms of gating and permeation, roles in normal physiological function, as well as the potential therapeutic use of pharmacological agents acting at glutamate receptors.
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AMPA Receptor Trafficking and Synaptic Plasticity
TL;DR: The growing literature that supports a critical role for AMPA receptors trafficking in LTP and LTD is reviewed, focusing on the roles proposed for specific AMPA receptor subunits and their interacting proteins.
Journal ArticleDOI
Homeostatic plasticity in the developing nervous system
TL;DR: Evidence is discussed from a number of systems that homeostatic synaptic plasticity is crucial for processes ranging from memory storage to activity-dependent development, and how these processes maintain stable activity states in the face of destabilizing forces is discussed.
Journal ArticleDOI
The molecular basis of CaMKII function in synaptic and behavioural memory.
TL;DR: Genetic mutations that prevent persistent activation of CaMKII block LTP, experience-dependent plasticity and behavioural memory, making this kinase a leading candidate in the search for the molecular basis of memory.
References
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A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal Article
The glutamate receptor ion channels
TL;DR: The cloning of cDNAs encoding glutamate receptor subunits, which occurred mainly between 1989 and 1992, stimulated the development of ionotropic glutamate receptors in the brain.
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Cloned Glutamate Receptors
TL;DR: The application of molecular cloning technology to the study of the glutamate receptor system has led to an explosion of knowledge about the structure, expression, and function of this most important fast excitatory transmitter system in the mammalian brain.
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Synaptic plasticity and memory: an evaluation of the hypothesis
TL;DR: It is concluded that a wealth of data support the notion that synaptic plasticity is necessary for learning and memory, but that little data currently supports the notion of sufficiency.
Journal Article
Mechanisms of intracellular protein transport
TL;DR: The general protein apparatus used by all eukaryotes for intracellular transport, including secretion and endocytosis, and for triggered exocyTosis of hormones and neurotransmitters, is uncovered.