Sugar for the brain: the role of glucose in physiological and pathological brain function
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TLDR
Recent advances in understanding how glucose metabolism sustains basic brain physiology are reviewed to form a comprehensive picture of the cooperation required between different systems and cell types, and the specific breakdowns in this cooperation that lead to disease.About:
This article is published in Trends in Neurosciences.The article was published on 2013-10-01 and is currently open access. It has received 1021 citations till now.read more
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2022 Alzheimer's disease facts and figures
TL;DR: The public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality and morbidity, use and costs of care, and the overall impact on family caregivers, the dementia workforce and society are described are described.
Role of Brain Insulin Receptor in Control of Body Weight and Reproduction
W. M. Saxton,J. Hicks,L. S. B. Goldstein,E. C. Raff,David Micklem,Jan Adams,Stefan Grünert,D. St Johnston +7 more
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Energy metabolism and inflammation in brain aging and Alzheimer's disease.
TL;DR: This review focuses on the alterations in energy metabolism and inflammatory responses and their connection via redox regulation in normal brain aging and Alzheimer's disease.
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Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro.
Cedric Bardy,Mark van den Hurk,Mark van den Hurk,Tameji Eames,Cynthia Marchand,Cynthia Marchand,Ruben V. Hernandez,Mariko Kellogg,Mark A.J. Gorris,Ben Galet,Vanessa Palomares,Joshua Brown,Anne G. Bang,Jerome Mertens,Lena Böhnke,Leah Boyer,Suzanne Simon,Fred H. Gage +17 more
TL;DR: A new neuronal medium is designed and tested in which the concentrations of inorganic salts, neuroactive amino acids, and energetic substrates are adjusted in which this medium adequately supports neuronal activity and survival of human neurons in culture.
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Methylglyoxal, a highly reactive dicarbonyl compound, in diabetes, its vascular complications and other age-related diseases
TL;DR: The mechanisms through which MGO is formed, its detoxification by the glyoxalase system, and its effect on biochemical pathways in relation to the development of diabetes, vascular complications of diabetes and other age-related diseases are summarized.
References
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The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat.
Louis Sokoloff,Martin Reivich,Charles Kennedy,Charles Kennedy,M. H. Des Rosiers,Clifford S. Patlak,Karen D. Pettigrew,O. Sakurada,M. Shinohara +8 more
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Pathobiology of ischaemic stroke: an integrated view
TL;DR: This article provides a framework that can be used to generate testable hypotheses and treatment strategies that are linked to the appearance of specific pathophysiological events within the ischaemic brain.
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Autophagy and the Integrated Stress Response
TL;DR: Autophagy is a cell biological process that is a central component of the integrated stress response and can be integrated with other cellular stress responses through parallel stimulation of autophagy and other stress responses by specific stress stimuli.
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Effect of Ischemia on Known Substrates and Cofactors of the Glycolytic Pathway in Brain
TL;DR: This is a record of the concentrations of the nonenzyme components of the Embden-Meyerhof system in mouse brain measured at brief intervals after the production of complete ischemia by decapitation, which resulted in increases in glycolytic rates of at least 4to 7-fold in different experimental groups of mice.
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Glial and neuronal control of brain blood flow.
David Attwell,Alastair M. Buchan,Serge Charpak,Martin Lauritzen,Brian A. MacVicar,Eric A. Newman +5 more
TL;DR: It is now recognized that neurotransmitter-mediated signalling has a key role in regulating cerebral blood flow, that much of this control is mediated by astrocytes, that oxygen modulates blood flow regulation, and that blood flow may be controlled by capillaries as well as by arterioles.