Journal ArticleDOI
Superparamagnetic iron oxide: Pharmacokinetics and toxicity
Ralph Weissleder,David D. Stark,Barry L. Engelstad,Bruce R. Bacon,Carolyn C. Compton,David L. White,P. Jacobs,Jason S. Lewis +7 more
TLDR
The results indicate that AMI-25 is a fully biocompatible potential contrast agent for MR and bioavailability similar to that of commercially available IV iron preparations within 7 days.Abstract:
The pharmacokinetics (distribution, metabolism, bioavailability, excretion) and toxicity (acute and subacute toxicity, mutagenicity) of a superparamagnetic iron oxide preparation (AMI-25), currently used in clinical trials, were evaluated by 59Fe radiotracer studies, measurements of relaxation times, the ability to reverse iron deficiency anemia, histologic examination, and laboratory parameters. One hour after administration of AMI-25 to rats (18 mumol Fe/kg; 1 mg Fe/kg), 82.6 +/- 0.3% of the administered dose was sequestered in the liver and 6.2 +/- 7.6% in the spleen. Peak concentrations of 59Fe were found in liver after 2 hr and in the spleen after 4 hr. 59Fe slowly cleared from liver (half-life, 3 days) and spleen (half-life, 4 days) and was incorporated into hemoglobin of erythrocytes in a time-dependent fashion. The half-time of the T2 effect on liver and spleen (24-48 hr) was shorter than the 59Fe clearance, indicating metabolism of AMI-25 into other forms of iron. IV administration of AMI-25 (30 mg Fe/kg) corrected iron-deficiency anemia and showed bioavailability similar to that of commercially available IV iron preparations within 7 days. No acute or subacute toxic effects were detected by histologic or serologic studies in rats or beagle dogs who received a total of 3000 mumol Fe/kg, 150 times the dose proposed for MR imaging of the liver. Our results indicate that AMI-25 is a fully biocompatible potential contrast agent for MR.read more
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Book ChapterDOI
Applications of magnetic nanoparticles in biomedicine
TL;DR: The physical principles underlying some current biomedical applications of magnetic nanoparticles are reviewed and the relevant physics of magnetic materials and their responses to applied magnetic fields are surveyed.
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Magnetic Nanoparticles in MR Imaging and Drug Delivery
TL;DR: A background on applications of MNPs as MR imaging contrast agents and as carriers for drug delivery and an overview of the recent developments in this area of research are provided.
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Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells.
Maïté Lewin,Nadia Carlesso,Ching-Hsuan Tung,Xiaowu Tang,David G. Cory,David T. Scadden,Ralph Weissleder +6 more
TL;DR: A cell labeling approach using short HIV-Tat peptides to derivatize superparamagnetic nanoparticles is developed, which efficiently internalized into hematopoietic and neural progenitor cells in quantities up to 10–30 pg of super paramagnetic iron per cell.
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Tomographic imaging using the nonlinear response of magnetic particles
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Magnetic nanoparticles: design and characterization, toxicity and biocompatibility, pharmaceutical and biomedical applications.
TL;DR: Biocompatibility, Pharmaceutical and Biomedical Applications L. Harivardhan Reddy,‡ Jose ́ L. Arias, Julien Nicolas,† and Patrick Couvreur*,†.
References
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Journal ArticleDOI
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Hershko C,Cook Jd,Finch Da +2 more
TL;DR: An interaction of the drug with parenchymal ferritin stores and not with iron released by heme catabolism is suggested, supported by the close correlation between DF-induced excretion and the fraction of the different paren chymal radioiron probes assimilated into parenchyma ferritIn stores.
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