Survival and metabolic function of syngeneic rat islet grafts transplanted in the omental pouch.
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TLDR
The results indicate that the omental pouch is a viable site which offers a safe, convenient and efficacious alternative to the renal subcapsular space to transplant islets in rodents.About:
This article is published in American Journal of Transplantation.The article was published on 2003-03-01 and is currently open access. It has received 138 citations till now. The article focuses on the topics: Transplantation & Islet.read more
Citations
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Islet transplantation as a treatment for diabetes - a work in progress.
TL;DR: This review discusses pancreatic islet-cell transplantation as an evolving procedure to provide type 1 diabetic patients with the possibility of an insulin-injection–free existence.
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Biological and Biomaterial Approaches for Improved Islet Transplantation
Ajit S. Narang,Ram I. Mahato +1 more
TL;DR: This review will critically address various insights developed in each individual strategy and for multipronged approaches, which will be helpful in achieving better outcomes of islet transplantation.
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Optimal implantation site for pancreatic islet transplantation
TL;DR: Since the first report of successful pancreatic islet transplantation to reverse hyperglycaemia in diabetic rodents, there has been great interest in determining the optimal site for implantation.
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Xenotransplantation of porcine neonatal islets of Langerhans and Sertoli cells: a 4-year study
Rafael Valdés-González,Luis M Dorantes,G. Nayely Garibay,Eduardo Bracho-Blanchet,Armando J. Mendez,Roberto Dávila-Pérez,Robert B. Elliott,Luis Terán,David J.G. White +8 more
TL;DR: Long-term cell survival with concurrent positive effects on metabolic control are possible by this technique, and the presence of insulin-positive cells in the transplant was demonstrated by immunohistology in all 4 patients.
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Islets transplanted in immunoisolation devices: a review of the progress and the challenges that remain.
TL;DR: Significant progress has been made in developing suitable materials that satisfy the need for biocompatibility, durability, and permselectivity, but the search is ongoing for a device that allows sufficient oxygen transfer while maintaining a barrier to immune cells and preventing rejection of the transplanted tissue.
References
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Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas
Paul E. Lacy,Mery Kostianovsky +1 more
TL;DR: A simple method for the isolation of intact islets from the normal rat pancreas is described, based upon disruption of the acinar parenchyma by injecting Hanks solution into the pancreatic duct system followed by incubation of the Pancreas in collagenase.
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Effect of Hypoxia on Insulin Secretion by Isolated Rat and Canine Islets of Langerhans
TL;DR: It is hypothesized that the effect of low pO2 on S is manifested through depletion of the energy stores of the β-cells, and may play a critical role in the effectiveness of transplanted islets before their revascularization and of immunoisolated islet implantation devices.
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Large scale isolation, growth, and function of porcine neonatal islet cells.
TL;DR: The results indicate that the neonatal porcine pancrease can be used as a source of large numbers of viable islet cells, which have the potential for growth both in vitro and in vivo, and exhibit the metabolic capacity to correct diabetes in nude mice.
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Vascular Endothelial Growth Factor Is the Major Angiogenic Factor in Omentum: Mechanism of the Omentum-Mediated Angiogenesis
Qing-Xue Zhang,Christopher J. Magovern,Charles A. Mack,Kurt T. Budenbender,Wilson Ko,Todd K. Rosengart +5 more
TL;DR: Data suggest that VEGF is the major angiogenic factor produced by omentum and possibly underlies the mechanism of omentsum-induced angiogenesis.
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