Journal ArticleDOI
Switching, induction of rapid cycling, and increased suicidality with antidepressants in bipolar patients: fact or overinterpretation?
TLDR
It appears that, at least, the switch risk, and perhaps also the risk for rapid cycling and new-onset suicidality have been overinterpreted, and this raises doubt about the efficacy of anti-depressants as a primary-treatment choice in bipolar depression.Abstract:
Antidepressants constitute a central cornerstone in the treatment of depressive syndromes. In bipolar patients, however, there is an ongoing controversy about their usefulness for at least 3 decades. Early reports, mainly concerning tricyclic antidepressants, have repeatedly pointed toward unfavorable side effects on the course of the disorder, namely switching into (hypo)mania, induction of rapid cycling, and increased risk of suicide. Most evidence for both unfavorable and favorable effects has been deducted, thus far, from small studies with methodological flaws. More substantiated evidence only recently became available. From this it appears that, at least, the switch risk, and perhaps also the risk for rapid cycling and new-onset suicidality have been overinterpreted. At the same time, these new data raise doubt about the efficacy of antidepressants as a primary-treatment choice in bipolar depression.read more
Citations
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Journal ArticleDOI
The International Society for bipolar Disorders (ISBD) task force report on antidepressant use in bipolar disorders
Isabella Pacchiarotti,David J. Bond,Ross J. Baldessarini,Willem A. Nolen,Heinz Grunze,Rasmus Wentzer Licht,Robert M. Post,Michael Berk,Guy M. Goodwin,Gary S. Sachs,Leonardo Tondo,Robert L. Findling,Eric A. Youngstrom,Mauricio Tohen,Juan Undurraga,Ana González-Pinto,Joseph F. Goldberg,Aysegul Yildiz,Lori L. Altshuler,Joseph R. Calabrese,Philip B. Mitchell,Michael E. Thase,Athanasios Koukopoulos,Francesc Colom,Mark A. Frye,Gin S Malhi,Konstantinos N. Fountoulakis,Gustavo H. Vázquez,Roy H. Perlis,Terence A. Ketter,Frederick Cassidy,Hagop S. Akiskal,Jean-Michel Azorin,Marc Valentí,Diego Hidalgo Mazzei,Beny Lafer,Tadafumi Kato,Lorenzo Mazzarini,Anabel Martínez-Arán,Gordon Parker,Daniel Souery,Ayşegül Özerdem,Susan L. McElroy,Paolo Girardi,Michael Bauer,Lakshmi N. Yatham,Carlos A. Zarate,Andrew A. Nierenberg,Boris Birmaher,Shigenobu Kanba,Rif S. El-Mallakh,Alessandro Serretti,Zoltán Rihmer,Allan H. Young,Georgios D. Kotzalidis,Glenda MacQueen,Charles L. Bowden,S. Nassir Ghaemi,Carlos López-Jaramillo,Janusz K. Rybakowski,Kyooseob Ha,Giulio Perugi,Siegfried Kasper,Jay D. Amsterdam,Robert M. A. Hirschfeld,Flávio Kapczinski,Eduard Vieta +66 more
TL;DR: A consensus was reached on 12 statements on the use of antidepressants in bipolar disorder, and antidepressants should be prescribed only as an adjunct to mood-stabilizing medications.
Journal ArticleDOI
The World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treatment of bipolar disorders: update 2012 on the long-term treatment of bipolar disorder.
Heinz Grunze,Eduard Vieta,Guy M. Goodwin,Charles L. Bowden,Rasmus Wentzer Licht,Hans-Jürgen Möller,Siegfried Kasper +6 more
TL;DR: The purpose is to supply a systematic overview of all scientific evidence pertaining to the long-term treatment of bipolar disorder in adults, and lithium continues to be the substance with the broadest base of evidence across treatment scenarios.
Journal ArticleDOI
The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders: Update 2010 on the treatment of acute bipolar depression.
Heinz Grunze,Eduard Vieta,Guy M. Goodwin,Charles L. Bowden,Rasmus Wentzer Licht,Hans-Jürgen Möller,Siegfried Kasper +6 more
TL;DR: Ten pharmacological monotherapies or combination treatments with at least limited positive evidence for efficacy in bipolar depression are identified, several of them still experimental and backed up only by a single study.
Journal ArticleDOI
The neurobiology of the switch process in bipolar disorder: a review.
Giacomo Salvadore,Jorge A. Quiroz,Rodrigo Machado-Vieira,Ioline D. Henter,Husseini K. Manji,Carlos A. Zarate +5 more
TL;DR: In this article, the authors summarize the clinical evidence regarding somatic interventions associated with switching, with a particular focus on the biological underpinnings presumably involved in the switch process.
Journal ArticleDOI
The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders: Update 2010 on the Treatment of Acute Bipolar Depression
Heinz Grunze,Eduard Vieta,Guy M. Goodwin,Charles L. Bowden,Rasmus Wentzer Licht,Hans-Jürgen Möller,Siegfried Kasper,Wfsbp Task +7 more
TL;DR: Ten pharmacological monotherapies or combination treatments with at least limited positive evidence for effi cacy in bipolar depression are identified, several of them still experimental and backed up only by a single study.
References
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Journal ArticleDOI
Suicidality in pediatric patients treated with antidepressant drugs.
TL;DR: Use of antidepressant drugs in pediatric patients is associated with a modestly increased risk of suicidality, and a meta-analysis was conducted to obtain overall suicidity risk estimates.
Journal ArticleDOI
Effectiveness of Adjunctive Antidepressant Treatment for Bipolar Depression
Gary S. Sachs,Andrew A. Nierenberg,Joseph R. Calabrese,Lauren B. Marangell,Stephen R. Wisniewski,Laszlo Gyulai,Edward S. Friedman,Charles L. Bowden,Mark D. Fossey,Michael J. Ostacher,Terence A. Ketter,Jayendra K. Patel,Peter Hauser,Daniel Rapport,James M. Martinez,Michael H. Allen,David J. Miklowitz,Michael W. Otto,Ellen B. Dennehy,Michael E. Thase +19 more
TL;DR: The use of adjunctive, standard antidepressant medication, as compared with the use of mood stabilizers, was not associated with increased efficacy or with increased risk of treatment-emergent affective switch.
Journal ArticleDOI
Efficacy of Olanzapine and Olanzapine-Fluoxetine Combination in the Treatment of Bipolar I Depression
Mauricio Tohen,Mauricio Tohen,Eduard Vieta,Joseph R. Calabrese,Terence A. Ketter,Gary S. Sachs,Charles L. Bowden,Philip B. Mitchell,Franca Centorrino,R.C. Risser,Robert W. Baker,Angela R. Evans,Karin Beymer,Sanjay Dubé,Sanjay Dubé,Gary D. Tollefson,Alan Breier +16 more
TL;DR: Olanzapine is more effective than placebo, and combined olanzapine-fluoxetine isMore effective than olanZapine and placebo in the treatment of bipolar I depression without increased risk of developing manic symptoms.
Journal ArticleDOI
Antidepressant-induced mania and cycle acceleration: a controversy revisited.
Lori L. Altshuler,Robert M. Post,Gabriele S. Leverich,Kirstin Mikalauskas,Ann Rosoff,Laura Ackerman +5 more
TL;DR: Antidepressant-induced mania may be a marker for increased vulnerability to antidepressant-induced cycle acceleration and is associated with younger age at first treatment and may be more likely to occur in women and in bipolar II patients.
Journal ArticleDOI
Clinical Factors in Lithium Carbonate Prophylaxis Failure
David L. Dunner,Ronald R. Fieve +1 more
TL;DR: Failure to prevent the recurrence of manic or depressive episodes was observed in 27 of 55 bipolar (manic-depressive) patients who received lithium carbonate for from 6 to 66 months.
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