Journal ArticleDOI
Synergistic effect of three benzopyrans isolated from Hypericum polyanthemum in U-373 MG glioblastoma cell line.
Ivana Grivicich,Alexandre de Barros Falcão Ferraz,Denise Heidrich Faria,Andrea Regner,Gilberto Schwartsmann,Amélia T. Henriques,Gilsane Lino von Poser,Adriana Brondani da Rocha +7 more
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The antiproliferative activity of three benzopyrans isolated from the chloroform extract of the aerial parts of Hypericum polyanthemum was analysed in order to determine their effect on the growth and cell cycle in the U‐373 MG glioblastoma cell line.Abstract:
The antiproliferative activity of three benzopyrans isolated from the chloroform extract of the aerial parts of Hypericum polyanthemum was analysed in order to determine their effect on the growth and cell cycle in the U-373 MG glioblastoma cell line. Compound 1 was less cytotoxic than compounds 2 and 3. A synergistic effect was noticed when the three benzopyrans were used simultaneously. The cytotoxicity noted could be related to an arrest in G2/M phase, leading to apoptosis in the U-373 MG glioblastoma cell line.read more
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Medicinal plants in Brazil: Pharmacological studies, drug discovery, challenges and perspectives.
TL;DR: Pre-clinical and clinical studies with some selected Brazilian medicinal plants in different areas of interest, conducted by research groups in Brazil and abroad are focused on, highlighting the Brazilian market of herbal products and the efforts of Brazilian scientists to develop new phytomedicines.
Journal ArticleDOI
Anti-ageing active ingredients from herbs and nutraceuticals used in traditional Chinese medicine: pharmacological mechanisms and implications for drug discovery.
TL;DR: Wang et al. as mentioned in this paper summarized the work done on the natural products from TCM that are reported to have anti-ageing effects, in the past two decades The effective anti-aging ingredients identified can be generally divided into flavonoids, saponins, polysaccharides, alkaloids and others.
Journal ArticleDOI
Potentiating therapeutic effects by enhancing synergism based on active constituents from traditional medicine.
Aihua Zhang,Hui Sun,Xijun Wang +2 more
TL;DR: The present review highlights the concept of synergy and gives some examples of synergistic effects of TCM, and provides an overview of the recent and potential developments of advancing drug discovery towards more agile development of targeted combination therapies from TCM.
Journal ArticleDOI
Supercritical fluid extraction and high performance liquid chromatographic determination of benzopyrans and phloroglucinol derivative in Hypericum polyanthemum
Simone Tasca Cargnin,Jéssica de Matos Nunes,Juliana Schulte Haas,Luís Fernando Baladão,Eduardo Cassel,Rubem M. F. Vargas,Sandra Beatriz Rech,Gilsane Lino von Poser +7 more
TL;DR: SFE presented higher selectivity than the n-hexane maceration, and the best condition to extract the target metabolites has been determined to be at 50 degrees C and for the high molecular-weight compound, uliginosin B, higher pressures were required.
Journal ArticleDOI
Leishmanicidal activity of lipophilic extracts of some Hypericum species.
Ana Paula Aquistapase Dagnino,Francisco Maikon Corrêa de Barros,Gari Vidal Ccana-Ccapatinta,Josiane Somariva Prophiro,Gilsane Lino von Poser,Pedro R. T. Romão +5 more
TL;DR: The promising results demonstrate the importance of the species of the genus Hypericum as source of compounds potentially useful for the treatment of leishmaniasis.
References
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Journal ArticleDOI
New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening
Philip Skehan,Ritsa Storeng,Dominic A. Scudiero,Anne Monks,James B. McMahon,David T. Vistica,Jonathan T. Warren,Heidi R. Bokesch,Susan Kenney,Michael R. Boyd +9 more
TL;DR: The SRB assay provides a sensitive measure of drug-induced cytotoxicity, is useful in quantitating clonogenicity, and is well suited to high-volume, automated drug screening.
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Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors
Ting-Chao Chou,Paul Talalay +1 more
TL;DR: A generalized method for analyzing the effects of multiple drugs and for determining summation, synergism and antagonism has been proposed and has been used to analyze experimental data obtained from enzymatic, cellular and animal systems.
Journal ArticleDOI
A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
TL;DR: A flow cytometric method for measuring the percentage of apoptotic nuclei after propidium iodide staining in hypotonic buffer is developed and shown an excellent correlation with the results obtained with both electrophoretic and colorimetric methods.
Journal ArticleDOI
Plants as a source of anti-cancer agents.
Gordon M. Cragg,David J. Newman +1 more
TL;DR: A number of promising new agents are in clinical development based on selective activity against cancer-related molecular targets, including flavopiridol and combretastin A4 phosphate, while some agents which failed in earlier clinical studies are stimulating renewed interest.
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