Journal ArticleDOI
Synthese von 2‐Amino‐3‐cyano‐pyrrolen
Hermann J. Roth,K. Eger +1 more
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TLDR
In this paper, a simple synthesis for 2-amino-3-cyano-pyrroles is described: condensation of α-hydroxyketones, primary amines and malonitrile.Abstract:
Es wird eine einfache Synthese fur 2-Amino-3-cyano-pyrrole beschrieben, die in der Kondensation von α-Hydroxyketonen, primaren Aminen und Malonitril besteht.
Synthesis of 2-Amino-3-cyano-pyrroles
A simple synthesis for 2-amino-3-cyano-pyrroles is described: condensation of α-hydroxyketones, primary amines and malonitrile.read more
Citations
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Active methylenes in the synthesis of a pyrrole motif: an imperative structural unit of pharmaceuticals, natural products and optoelectronic materials
TL;DR: A review on pyrrole based pharmaceuticals, natural products and optoelectronic materials can be found in this paper, together with novel reports from our laboratory recently (till 2015).
Journal ArticleDOI
Synthesis of certain pyrrole derivatives as antimicrobial agents.
TL;DR: The synthesis and in vitro microbiological evaluation of a series of pyrrole derivatives showed potent antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi.
Journal ArticleDOI
Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis
Kevin J. Frankowski,Chen Wang,Samarjit Patnaik,Frank J. Schoenen,Noel Southall,Dandan Li,Yaroslav Teper,Wei Sun,Irawati Kandela,Deqing Hu,Christopher R. Dextras,Zachary Knotts,Yansong Bian,John Norton,Steve Titus,Marzena Anna Lewandowska,Yiping Wen,Katherine I. Farley,Lesley A. Mathews Griner,Jamey Sultan,Zhaojing Meng,Ming Zhou,Tomas Vilimas,Astin Powers,Serguei Kozlov,Kunio Nagashima,Humair S. Quadri,Min Fang,Charles Long,Ojus Khanolkar,Warren Chen,Jinsol Kang,Helen Huang,Eric Chow,Esthermanya Goldberg,Coral Feldman,Romi Xi,Hyerim Kim,G. Gary Sahagian,Susan J. Baserga,Andrew P. Mazar,Marc Ferrer,Wei Zheng,Ali Shilatifard,Jeffrey Aubé,Udo Rudloff,Juan J. Marugan,Sui Huang +47 more
TL;DR: It is discovered that metarrestin inhibited tumor invasion and metastasis in multiple mouse models of cancer and prolonged the animals’ survival, suggesting its potential relevance for translation to patients.
Journal ArticleDOI
Chiral pyrrolo[2,3-d]pyrimidine and pyrimido[4,5-b]indole derivatives: structure-activity relationships of potent, highly stereoselective A1-adenosine receptor antagonists.
TL;DR: A new class of very potent A1AR antagonists has been identified, namely, 2-phenyl-7-deazaadenines bearing a substituent at the exocyclic amino group (N4-substituted pyrrolo[2,3-d]pyrimidines), which should be an interesting compound for in vivo evaluation.
Journal ArticleDOI
Structure-activity relationship study and optimisation of 2-aminopyrrole-1-benzyl-4,5-diphenyl-1H-pyrrole-3-carbonitrile as a broad spectrum metallo-β-lactamase inhibitor
Ross P. McGeary,Daniel T.C. Tan,Christopher Selleck,Marcelo Monteiro Pedroso,Hanna E. Sidjabat,Gerhard Schenk +5 more
TL;DR: The N-benzoyl derivative of 5a retained potent in vitro activity against each of MBLs tested (with inhibition constants in the low μM range) and significantly enhanced the sensitivity of IMP-1, CphA- or AIM-1-producing cell cultures towards meropenem.
References
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Journal ArticleDOI
Heterocyclen aus CH‐aciden Nitrilen, IX. Über die Reaktion von α‐Hydroxy‐ketonen mit Malodinitril
TL;DR: α-hydroxy-ketone reagieren mit Malodinitril in Gegenwart von Basen bei Raumtemperatur zu substituierten 2-Amino-3-cyan-furanen, uber deren Folgereaktionen mit Maleinsaureanhydrid sowie mit Formamid berichtet wird as discussed by the authors.
Journal ArticleDOI
Tetrahydroindol‐4‐one aus Enaminen cyclischer β‐Dicarbonylverbindungen
Hermann J. Roth,H.‐E. Hagen +1 more
TL;DR: In this paper, enamines of cyclic β-diketones yield 2,3disubstituted 4,5,6,7-tetrahydro-indole-4-ones by condensation with α-ketols.
Journal ArticleDOI
Synthese phenylsubstituierter Pyrrole
H. J. Roth,H. George,F. Assadi +2 more
TL;DR: In this article, the synthesis of 2-anilino-2-phenyl-acetophenone with the carbonyl-compounds R1COCH2R2, catalized by formic acid leads to 1,2,3-triphenylpyrroles with the substituted groups R1 and R2.
Journal ArticleDOI
Eine einfache, gezielte Synthese substituierter 1,2,3‐Triphenylpyrrole
Journal ArticleDOI
Zur Synthese substituierter Pyrrole
H. George,Hermann J. Roth +1 more
TL;DR: In this paper, the synthesis of substituted pyrroles is described, which leads to substitution of alicyclic ketones, primary amines and α-hydroxyketones by acid and basic catalysis.