Journal ArticleDOI
Synthesis and radioprotective effects of adamantyl substituted 1,4-dihydropyridine derivatives
Reads0
Chats0
TLDR
A series of 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diesters substituted at the N-1 and/or C-4 positions of the dihydropyrsidine ring synthesized afforded better radioprotection than those without this substituent.About:
This article is published in Bioorganic & Medicinal Chemistry.The article was published on 1998-05-01. It has received 67 citations till now. The article focuses on the topics: Dihydropyridine.read more
Citations
More filters
Journal ArticleDOI
Recent advances in new multicomponent synthesis of structurally diversified 1,4-dihydropyridines
Jie-Ping Wan,Yunyun Liu +1 more
TL;DR: In this article, the advances on the synthesis of structurally diversified 1,4-Dihydropyridines through new multicomponent reactions beyond the classical Hantzsch reaction are reviewed.
Journal ArticleDOI
Kojic acid and its manganese and zinc complexes as potential radioprotective agents
TL;DR: The naturally occurring fungal metabolite kojic acid and its manganese and zinc complexes showed that these compounds exhibited significant radioprotective effects against lethal dose of gamma-irradiation in mice.
Journal ArticleDOI
Heterogeneous ditopic ZnFe2O4 catalyzed synthesis of 4H-pyrans: further conversion to 1,4-DHPs and report of functional group interconversion from amide to ester
TL;DR: In this article, the first attempt towards the synthesis of 4H-pyran-3-carboxylate was made using water as a reaction medium as well as a medium for synthesis of the catalyst.
Journal ArticleDOI
A grinding-induced catalyst- and solvent-free synthesis of highly functionalized 1,4-dihydropyridines via a domino multicomponent reaction
Atul Kumar,Siddharth Sharma +1 more
TL;DR: A grinding-induced catalyst and solvent-free domino multicomponent reaction for the synthesis of 1,4-dihydropyridines has been developed using aldehydes, amines, DEAD (diethyl acetylenedicarboxylate), and malononitrile/ethyl cyanoacetate as discussed by the authors.
Journal ArticleDOI
A new three-component domino synthesis of 1,4-dihydropyridines
TL;DR: In this article, it was shown that CAN catalyzes the three-component domino reaction between aromatic amines, α, β-unsaturated aldehydes, and ethyl acetoacetate, providing an efficient new entry into 1,4-dihydropyridines.
References
More filters
Journal ArticleDOI
Toxicity of WR-2721 administered in single and multiple doses
Morton M. Kligerman,Donna J. Glover,Andrew T. Turrisi,A.Lorraine Norfleet,John M. Yuhas,Lawrence R. Coia,Charles B. Simone,John H. Glick,Robert L. Goodman +8 more
TL;DR: An Acceptable Tolerated Dose (ATD) of 740 mg/m2 infused in 15 minutes has been established and is currently used in Phase II studies and there is no suggestion of tumor protection.
Journal ArticleDOI
Advances in Radioprotection through the Use of Combined Agent Regimens
TL;DR: Improved radioprotection and reduced lethal toxicity of the phosphorothioate WR-2721 was observed when it was administered in combination with metals (selenium, zinc or copper).
Journal ArticleDOI
Antimutagenic effects of radioprotector WR-2721 against fission-spectrum neurons and 60Co gamma-rays in mice.
TL;DR: The antimutagenic effects of the radiation protective agent, S-2-(3-aminopropylamino)ethylphosphorothioic acid (WR-2721) are effective antimutagens and could be in their use to protect against radiation- and/or chemotherapy-induced genotoxic damage to normal cells.
Journal ArticleDOI
Antioxidant effect of calcium antagonists on microsomai membranes isolated from different brain areas
TL;DR: The data suggest that Ca2+ antagonists inhibit peroxidation of the membrane lipid bilayer by a free radical scavenger effect that may be related to their chemical structure.
Journal ArticleDOI
Radioprotective effects of calcium antagonists used alone or with other types of radioprotectors
TL;DR: Diltiazem, a benzothiazepine calcium channel blocker used widely in cardiovascular therapy, protected mice against death by ionizing radiation and could be administered subcutaneously or intraperitoneally, providing modest dose reduction factors but without the prohibitive side effects of aminothiols.
Related Papers (5)
Recent developments in isocyanide based multicomponent reactions in applied chemistry
Recent advances in new multicomponent synthesis of structurally diversified 1,4-dihydropyridines
Jie-Ping Wan,Yunyun Liu +1 more