Journal ArticleDOI
Synthesis, biological evaluation, and docking studies of 3-(substituted)-aryl-5-(9-methyl-3-carbazole)-1H-2-pyrazolines as potent anti-inflammatory and antioxidant agents.
Babasaheb P. Bandgar,Laxman K. Adsul,Hemant V. Chavan,Shivkumar S. Jalde,Sadanand N. Shringare,Rafique Shaikh,Rohan J. Meshram,Rajesh N. Gacche,Vijay H. Masand +8 more
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TLDR
Molecular docking result, along with the biological assay data, suggested that compound 5c was a potential anti-inflammatory agent.About:
This article is published in Bioorganic & Medicinal Chemistry Letters.The article was published on 2012-09-15. It has received 98 citations till now. The article focuses on the topics: Docking (molecular) & DPPH.read more
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Biological potential of carbazole derivatives.
TL;DR: The present review focuses on the recent progress in knowledge on various biological properties of classical, tricyclic carbazole derivatives from 2010 until now.
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Recent Developments and Biological Activities of N-Substituted Carbazole Derivatives: A Review.
TL;DR: The medicinal importance of recently synthesized N-substituted carbazoles is reviewed due to their therapeutic potential against neurological disorders and cell proliferation.
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Schiff's bases of quinazolinone derivatives: Synthesis and SAR studies of a novel series of potential anti-inflammatory and antioxidants.
TL;DR: Preliminary structure-activity relationship revealed that the compounds 17, 18, 23, 24, 25, 27 and 28 with electron donating moiety (OH, OCH3) were found to be excellent antioxidants and compounds 9, 10, 11 and 12 with electron withdrawing moiety ("Cl, NO2") were foundto be excellent anti-inflammatory agents.
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Recent advancement in the discovery and development of COX-2 inhibitors: Insight into biological activities and SAR studies (2008-2019).
Vrinda Sharma,Parth Bhatia,Ozair Alam,Mohd. Javed Naim,Farah Nawaz,Aadil Ahmad Sheikh,Mukund Jha +6 more
TL;DR: This review aims to aid medicinal chemists in the design and discovery of better COX-2 inhibitors constructed on these five heterocyclic pharmacophores by exploring the addition of various moieties to these core rings and their structure-activity relationship along with their molecular modelling data.
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Discovery of novel N-substituted carbazoles as neuroprotective agents with potent anti-oxidative activity.
Daqian Zhu,Meihui Chen,Min Li,Bingling Luo,Yang Zhao,Peng Huang,Fengtian Xue,Simona Rapposelli,Rongbiao Pi,Shijun Wen +9 more
TL;DR: One of the new compounds, 6, showed the best neuroprotective effects, which might result from its anti-oxidative activity with a GSH-independent mechanism, and might provide an alternative strategy for the development of novel carbazole derivatives for the treatment of CNS diseases such as Alzheimer's disease.
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Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
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Antioxidant Determinations by the Use of a Stable Free Radical
TL;DR: In this paper, the chemical nature of the antioxidant is known and a test specific for the compound or group of interest; for example, the nitroprusside test for sulphydryl groups.
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Free radicals, metals and antioxidants in oxidative stress-induced cancer
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Dietary carcinogens and anticarcinogens Oxygen radicals and degenerative diseases
TL;DR: Dietary intake of natural antioxidants could be an important aspect of the body's defense mechanism against these agents of cancer and other age-related diseases.
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Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase
TL;DR: BF 389, an experimental drug currently being tested in humans, was the most potent and most selective inhibitor of COX-2 in intact cells, indicating there are clear pharmacological differences between the two enzymes.