Taking a "good" look at free radicals in the aging process.
TLDR
It is proposed that ROS are tightly associated with aging because they play a role in mediating a stress response to age-dependent damage and could generate the observed correlation between aging and ROS without implying that ROS damage is the earliest trigger or main cause of aging.About:
This article is published in Trends in Cell Biology.The article was published on 2011-10-01 and is currently open access. It has received 517 citations till now. The article focuses on the topics: Free-radical theory of aging & Oxidative stress.read more
Citations
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Journal ArticleDOI
The Hallmarks of Aging
TL;DR: Nine tentative hallmarks that represent common denominators of aging in different organisms are enumerated, with special emphasis on mammalian aging, to identify pharmaceutical targets to improve human health during aging, with minimal side effects.
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ROS Function in Redox Signaling and Oxidative Stress
TL;DR: It is argued that redox biology, rather than oxidative stress, underlies physiological and pathological conditions.
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Physiological roles of mitochondrial reactive oxygen species.
Laura A. Sena,Navdeep S. Chandel +1 more
TL;DR: More and more evidence suggests that mROS are critical for healthy cell function, and this evidence is discussed following some background on the generation and regulation ofmROS.
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ROS Are Good.
TL;DR: This Opinion focuses on the possibility that ROS are beneficial to plants, supporting cellular proliferation, physiological function, and viability, and that maintaining a basal level of ROS in cells is essential for life.
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The emerging role of reactive oxygen and nitrogen species in redox biology and some implications for plasma applications to medicine and biology
TL;DR: The importance of ROS and RNS to plant biology has been relatively little appreciated in the plasma biomedicine community, but it appears that there are opportunities for useful applications of plasmas in this area as well.
References
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Journal ArticleDOI
Free Radicals in the Physiological Control of Cell Function
TL;DR: There is growing evidence that aging involves, in addition, progressive changes in free radical-mediated regulatory processes that result in altered gene expression.
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Aging: A Theory Based on Free Radical and Radiation Chemistry
TL;DR: It seems possible that one factor in aging may be related to deleterious side attacks of free radicals (which are normally produced in the course of cellular metabolism) on cell constituents.
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How mitochondria produce reactive oxygen species.
TL;DR: The description outlined here facilitates the understanding of factors that favour mitochondrial ROS production and develops better methods to measure mitochondrial O2•− and H2O2 formation in vivo, as uncertainty about these values hampers studies on the role of mitochondrial ROS in pathological oxidative damage and redox signalling.
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Mitochondrial formation of reactive oxygen species.
TL;DR: This review describes the main mitochondrial sources of reactive species and the antioxidant defences that evolved to prevent oxidative damage in all the mitochondrial compartments and discusses various physiological and pathological scenarios resulting from an increased steady state concentration of mitochondrial oxidants.
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Mitochondria, Oxidants, and Aging
TL;DR: The evidence is reviewed that both supports and conflicts with the free radical theory of aging and the growing link between mitochondrial metabolism, oxidant formation, and the biology of aging is examined.