Targeting autophagy with natural products to prevent SARS-CoV-2 infection.
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TLDR
In this paper, natural products capable of interfering with SARS-CoV-2 cellular infection and replication through their action on autophagy have been reported as adjuvant therapeutics for the management of COVID-19 pandemic.About:
This article is published in Journal of Traditional and Complementary Medicine.The article was published on 2021-10-14 and is currently open access. It has received 10 citations till now. The article focuses on the topics: Autophagy & Biology.read more
Citations
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Computational studies on the interaction of SARS-CoV-2 Omicron SGp RBD with human receptor ACE2, limonin and glycyrrhizic acid
Seshu Vardhan,Suban K. Sahoo +1 more
TL;DR: In this article , the interactions of SARS-CoV-2 spike glycoprotein receptor-binding domain (SGp RBD) of the three variants (Omicron, Delta, and WT) with the receptor hACE2.1.
Journal ArticleDOI
Exosomes, autophagy and ER stress pathways in human diseases: Cross-regulation and therapeutic approaches.
Babak Jahangiri,Ali Kian Saei,Patience O. Obi,Narjes Asghari,Shahrokh Lorzadeh,Shirin Hekmatirad,Marveh Rahmati,Fatemeh Velayatipour,Mohammad Hossein Asghari,Ayesha Saleem,Mohammad Amin Moosavi +10 more
TL;DR: In this paper , the authors review the available information on the mechanisms that control autophagy, ER stress and EV pathways, with the view that a better understanding of their crosstalk and balance may improve our knowledge on the pathogenesis and treatment of human diseases, where these pathways are dysregulated.
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Further quantitative in silico analysis of SARS-CoV-2 S-RBD Omicron BA.4, BA.5, BA.2.75, BQ.1, and BQ.1.1 transmissibility
TL;DR: In this paper , the Covid-19 variants' transmissibility was further quantitatively analyzed in silico to study the binding strength with ACE-2 and find the binding inhibitors.
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Recent Progress in the Development of Opaganib for the Treatment of Covid-19
TL;DR: In this article , a tripartite model by which opaganib suppresses infection and replication of SARS-CoV-2 by inhibiting SK2, DES1 and GCS was presented.
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Wheat Germ Spermidine and Clove Eugenol in Combination Stimulate Autophagy In Vitro Showing Potential in Supporting the Immune System against Viral Infections
Francesca Truzzi,Anne Whittaker,Eros D'Amen,Camilla Tibaldi,A. Abate,Maria Chiara Valerii,Enzo Spisni,Giovanni Dinelli +7 more
TL;DR: Comparable benefits of SPD, EUG and SPD + EUG in inducing autophagy and reducing inflammation in vitro and could show promise for COVID-19 risk groups are shown.
References
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Probing the impact of quercetin-7-O-glucoside on influenza virus replication influence
TL;DR: Isolated compound Q7G showed strong inhibition activity against influenza A and B viruses and reduced virus-induced ROS and autophagy formation, and targeted viral RNA polymerase for further probing.
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Berberine and Obatoclax Inhibit SARS-Cov-2 Replication in Primary Human Nasal Epithelial Cells In Vitro.
Finny S. Varghese,Esther van Woudenbergh,Gijs J. Overheul,Marc J. Eleveld,Lisa Kurver,Niels van Heerbeek,Arjan van Laarhoven,Pascal Miesen,Gerco den Hartog,Marien I. de Jonge,Ronald P. van Rij +10 more
TL;DR: In this paper, the authors demonstrate that berberine and obatoclax, two broad-spectrum antiviral compounds, are effective against multiple isolates of SARS-CoV-2.
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Potential treatment with Chinese and Western medicine targeting NSP14 of SARS-CoV-2.
TL;DR: The compounds including Saquinavir, Hypericin, Baicalein and Bromocriptine, could bind the N-terminus and C-terminu of the homology model of the SARS-CoV-2 Nsp14, providing as a candidate drug against SARS -CoV -2 for further study.
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In silico virtual screening, characterization, docking and molecular dynamics studies of crucial SARS-CoV-2 proteins.
TL;DR: Baicalin and Limonin which is largely used in traditional Indian medicine system is found to inhibit the human ACE2 receptor (making it inefficient in binding to the receptor binding domain of SARS-CoV-2) in combination to be studied in vitro and in vivo against COVID-19.
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The inhibitory effects of PGG and EGCG against the SARS-CoV-2 3C-like protease.
Wei Chung Chiou,Khromova Galina Alekseevna, Kamalov Ikram Saidakbarovich, Makhamadalieva Malika Alievna,Jui Chieh Chen,Yun Ti Chen,Jinn-Moon Yang,Lih Hwa Hwang,Yi Shuan Lyu,Hsin Yi Yang,Cheng Huang +8 more
TL;DR: In this article, a fluorescence resonance energy transfer (FRET)-based method was used to assess the proteolytic activity of SARS-CoV-2 3CLpro using intramolecularly quenched fluorogenic peptide substrates corresponding to the cleavage sequence.