Targeting autophagy with natural products to prevent SARS-CoV-2 infection.
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TLDR
In this paper, natural products capable of interfering with SARS-CoV-2 cellular infection and replication through their action on autophagy have been reported as adjuvant therapeutics for the management of COVID-19 pandemic.About:
This article is published in Journal of Traditional and Complementary Medicine.The article was published on 2021-10-14 and is currently open access. It has received 10 citations till now. The article focuses on the topics: Autophagy & Biology.read more
Citations
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Computational studies on the interaction of SARS-CoV-2 Omicron SGp RBD with human receptor ACE2, limonin and glycyrrhizic acid
Seshu Vardhan,Suban K. Sahoo +1 more
TL;DR: In this article , the interactions of SARS-CoV-2 spike glycoprotein receptor-binding domain (SGp RBD) of the three variants (Omicron, Delta, and WT) with the receptor hACE2.1.
Journal ArticleDOI
Exosomes, autophagy and ER stress pathways in human diseases: Cross-regulation and therapeutic approaches.
Babak Jahangiri,Ali Kian Saei,Patience O. Obi,Narjes Asghari,Shahrokh Lorzadeh,Shirin Hekmatirad,Marveh Rahmati,Fatemeh Velayatipour,Mohammad Hossein Asghari,Ayesha Saleem,Mohammad Amin Moosavi +10 more
TL;DR: In this paper , the authors review the available information on the mechanisms that control autophagy, ER stress and EV pathways, with the view that a better understanding of their crosstalk and balance may improve our knowledge on the pathogenesis and treatment of human diseases, where these pathways are dysregulated.
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Further quantitative in silico analysis of SARS-CoV-2 S-RBD Omicron BA.4, BA.5, BA.2.75, BQ.1, and BQ.1.1 transmissibility
TL;DR: In this paper , the Covid-19 variants' transmissibility was further quantitatively analyzed in silico to study the binding strength with ACE-2 and find the binding inhibitors.
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Recent Progress in the Development of Opaganib for the Treatment of Covid-19
TL;DR: In this article , a tripartite model by which opaganib suppresses infection and replication of SARS-CoV-2 by inhibiting SK2, DES1 and GCS was presented.
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Wheat Germ Spermidine and Clove Eugenol in Combination Stimulate Autophagy In Vitro Showing Potential in Supporting the Immune System against Viral Infections
Francesca Truzzi,Anne Whittaker,Eros D'Amen,Camilla Tibaldi,A. Abate,Maria Chiara Valerii,Enzo Spisni,Giovanni Dinelli +7 more
TL;DR: Comparable benefits of SPD, EUG and SPD + EUG in inducing autophagy and reducing inflammation in vitro and could show promise for COVID-19 risk groups are shown.
References
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Berberine suppresses influenza virus-triggered NLRP3 inflammasome activation in macrophages by inducing mitophagy and decreasing mitochondrial ROS
TL;DR: Results suggest that restricting NLRP3 inflammasome activation by decreasing ROS generation through mitophagy induction may be crucial for the BBR‐mediated alleviation of influenza virus‐induced inflammatory lesions.
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Identifying the natural polyphenol catechin as a multi-targeted agent against SARS-CoV-2 for the plausible therapy of COVID-19: an integrated computational approach.
Chandra Bhushan Mishra,Preeti Pandey,Ravi Datta Sharma,Zubbair Malik,Raj Kumar Mongre,Andrew M. Lynn,Rajendra Prasad,Raok Jeon,Amresh Prakash +8 more
TL;DR: In this article, the authors report a comprehensive computational approach to identify the multi-targeted drug molecules against the SARS-CoV-2 proteins, which are crucially involved in the viral-host interaction, replication of the virus inside the host, disease progression and transmission of coronavirus infection.
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A ravenous defense: canonical and non-canonical autophagy in immunity.
TL;DR: Both canonical autophagy and the molecularly related, yet divergent pathways non-canonical autophagic are key players in proper host defense and allow us an opportunity to tailor infectious disease intervention and treatment to its specific pathway.
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Implications of the Novel Mutations in the SARS-CoV-2 Genome for Transmission, Disease Severity, and the Vaccine Development
TL;DR: In this paper, the authors discussed the effects of novel mutations in the SARS-CoV-2 genome on transmission, clinical outcomes and vaccine development, and the impact of the mutation on the rate of transmission between people, disease severity and the vaccine and therapeutic development.
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High-Throughput Screening for Anti–Influenza A Virus Drugs and Study of the Mechanism of Procyanidin on Influenza A Virus–Induced Autophagy
Jianping Dai,Gefei Wang,Wei-Zhong Li,Lin Zhang,Jia-Cai Yang,Xiangfeng Zhao,Xiaoxuan Chen,Yanxuan Xu,Kangsheng Li +8 more
TL;DR: It is found that procyanidin could inhibit the IAV replication at several stages of the life cycle and is identified as a novel and promising anti-IAV agent.