Targeting autophagy with natural products to prevent SARS-CoV-2 infection.
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TLDR
In this paper, natural products capable of interfering with SARS-CoV-2 cellular infection and replication through their action on autophagy have been reported as adjuvant therapeutics for the management of COVID-19 pandemic.About:
This article is published in Journal of Traditional and Complementary Medicine.The article was published on 2021-10-14 and is currently open access. It has received 10 citations till now. The article focuses on the topics: Autophagy & Biology.read more
Citations
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Computational studies on the interaction of SARS-CoV-2 Omicron SGp RBD with human receptor ACE2, limonin and glycyrrhizic acid
Seshu Vardhan,Suban K. Sahoo +1 more
TL;DR: In this article , the interactions of SARS-CoV-2 spike glycoprotein receptor-binding domain (SGp RBD) of the three variants (Omicron, Delta, and WT) with the receptor hACE2.1.
Journal ArticleDOI
Exosomes, autophagy and ER stress pathways in human diseases: Cross-regulation and therapeutic approaches.
Babak Jahangiri,Ali Kian Saei,Patience O. Obi,Narjes Asghari,Shahrokh Lorzadeh,Shirin Hekmatirad,Marveh Rahmati,Fatemeh Velayatipour,Mohammad Hossein Asghari,Ayesha Saleem,Mohammad Amin Moosavi +10 more
TL;DR: In this paper , the authors review the available information on the mechanisms that control autophagy, ER stress and EV pathways, with the view that a better understanding of their crosstalk and balance may improve our knowledge on the pathogenesis and treatment of human diseases, where these pathways are dysregulated.
Journal ArticleDOI
Further quantitative in silico analysis of SARS-CoV-2 S-RBD Omicron BA.4, BA.5, BA.2.75, BQ.1, and BQ.1.1 transmissibility
TL;DR: In this paper , the Covid-19 variants' transmissibility was further quantitatively analyzed in silico to study the binding strength with ACE-2 and find the binding inhibitors.
Journal ArticleDOI
Recent Progress in the Development of Opaganib for the Treatment of Covid-19
TL;DR: In this article , a tripartite model by which opaganib suppresses infection and replication of SARS-CoV-2 by inhibiting SK2, DES1 and GCS was presented.
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Wheat Germ Spermidine and Clove Eugenol in Combination Stimulate Autophagy In Vitro Showing Potential in Supporting the Immune System against Viral Infections
Francesca Truzzi,Anne Whittaker,Eros D'Amen,Camilla Tibaldi,A. Abate,Maria Chiara Valerii,Enzo Spisni,Giovanni Dinelli +7 more
TL;DR: Comparable benefits of SPD, EUG and SPD + EUG in inducing autophagy and reducing inflammation in vitro and could show promise for COVID-19 risk groups are shown.
References
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Journal ArticleDOI
In vitro evaluation of antiviral activity of single and combined repurposable drugs against SARS-CoV-2.
Andrés Pizzorno,Blandine Padey,Julia Dubois,Thomas Julien,Aurélien Traversier,Victoria Dulière,Pauline Brun,Bruno Lina,Manuel Rosa-Calatrava,Olivier Terrier +9 more
TL;DR: In vitro antiviral activities of a shortlist of compounds, known for their cellular broad-spectrum activities, together with drugs that are currently under evaluation in clinical trials for COVID-19 patients were evaluated.
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Flavonoids with inhibitory activity against SARS-CoV-2 3CLpro.
TL;DR: This study suggests important scaffolds to design 3CLpro inhibitors to develop antiviral agents or health-foods and dietary supplements to cope with SARS-CoV-2.
Journal ArticleDOI
Coronavirus interactions with the cellular autophagy machinery.
Katelyn Miller,Marisa McGrath,Zhiqiang Hu,Sohha Ariannejad,Stuart Weston,Matthew B. Frieman,William T. Jackson +6 more
TL;DR: There is evidence that many coronaviruses induce autophagy, although some of these viruses halt the progression of the pathway prior to autophagic degradation, so cataloging virus-host interactions is crucial for understanding disease pathogenesis, especially with the global challenge of SARS-CoV-2 and COVID-19.
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The Autophagy Regulator Rubicon Is a Feedback Inhibitor of CARD9-Mediated Host Innate Immunity
Chul-Su Yang,Mary A. Rodgers,Chan Ki Min,Jong-Soo Lee,Jong-Soo Lee,Lara M. Kingeter,June-Yong Lee,Ambrose Jong,Igor Kramnik,Xin Lin,Jae U. Jung +10 more
TL;DR: It is shown Rubicon is a physiological feedback inhibitor of CBM-mediated PRR signaling, preventing unbalanced proinflammatory responses and may function to coordinate various immune responses against microbial infection.
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Drug Screening for Autophagy Inhibitors Based on the Dissociation of Beclin1-Bcl2 Complex Using BiFC Technique and Mechanism of Eugenol on Anti-Influenza A Virus Activity
Jianping Dai,Xiangfeng Zhao,Jun Zeng,Qian-Ying Wan,Jia-Cai Yang,Wei-Zhong Li,Xiaoxuan Chen,Gefei Wang,Kangsheng Li +8 more
TL;DR: A drug screening model based on the inhibition of the dissociation of Beclin1-Bcl2 heterodimer, an important negative regulator of autophagy, using bimolecular fluorescence complementation (BiFC) technique is established and eugenol is found as a promising inhibitor for Autophagy and IAV infection.