Targeting autophagy with natural products to prevent SARS-CoV-2 infection.
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TLDR
In this paper, natural products capable of interfering with SARS-CoV-2 cellular infection and replication through their action on autophagy have been reported as adjuvant therapeutics for the management of COVID-19 pandemic.About:
This article is published in Journal of Traditional and Complementary Medicine.The article was published on 2021-10-14 and is currently open access. It has received 10 citations till now. The article focuses on the topics: Autophagy & Biology.read more
Citations
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Computational studies on the interaction of SARS-CoV-2 Omicron SGp RBD with human receptor ACE2, limonin and glycyrrhizic acid
Seshu Vardhan,Suban K. Sahoo +1 more
TL;DR: In this article , the interactions of SARS-CoV-2 spike glycoprotein receptor-binding domain (SGp RBD) of the three variants (Omicron, Delta, and WT) with the receptor hACE2.1.
Journal ArticleDOI
Exosomes, autophagy and ER stress pathways in human diseases: Cross-regulation and therapeutic approaches.
Babak Jahangiri,Ali Kian Saei,Patience O. Obi,Narjes Asghari,Shahrokh Lorzadeh,Shirin Hekmatirad,Marveh Rahmati,Fatemeh Velayatipour,Mohammad Hossein Asghari,Ayesha Saleem,Mohammad Amin Moosavi +10 more
TL;DR: In this paper , the authors review the available information on the mechanisms that control autophagy, ER stress and EV pathways, with the view that a better understanding of their crosstalk and balance may improve our knowledge on the pathogenesis and treatment of human diseases, where these pathways are dysregulated.
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Further quantitative in silico analysis of SARS-CoV-2 S-RBD Omicron BA.4, BA.5, BA.2.75, BQ.1, and BQ.1.1 transmissibility
TL;DR: In this paper , the Covid-19 variants' transmissibility was further quantitatively analyzed in silico to study the binding strength with ACE-2 and find the binding inhibitors.
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Recent Progress in the Development of Opaganib for the Treatment of Covid-19
TL;DR: In this article , a tripartite model by which opaganib suppresses infection and replication of SARS-CoV-2 by inhibiting SK2, DES1 and GCS was presented.
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Wheat Germ Spermidine and Clove Eugenol in Combination Stimulate Autophagy In Vitro Showing Potential in Supporting the Immune System against Viral Infections
Francesca Truzzi,Anne Whittaker,Eros D'Amen,Camilla Tibaldi,A. Abate,Maria Chiara Valerii,Enzo Spisni,Giovanni Dinelli +7 more
TL;DR: Comparable benefits of SPD, EUG and SPD + EUG in inducing autophagy and reducing inflammation in vitro and could show promise for COVID-19 risk groups are shown.
References
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Inhibition of Rabies Virus by 1,2,3,4,6-Penta-O-galloyl-β-d-Glucose Involves mTOR-Dependent Autophagy
TL;DR: It is found that PGG not only suppressed viral adsorption and entry, but also directly inactivated RABV through suppression of autophagy by mediating activation of the mTOR-dependentAutophagy signaling pathway.
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Kurarinone Inhibits HCoV-OC43 Infection by Impairing the Virus-Induced Autophagic Flux in MRC-5 Human Lung Cells
TL;DR: Kurarinone inhibited HCoV-OC43 infection in human lung fibroblast MRC-5 cells in a dose-dependent manner with an IC50 of 3.458 ± 0.101 µM, and was found to inhibit viral replication via its capacity to impair the virus-induced autophagic flux.
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Resveratrol‑loaded nanoparticles inhibit enterovirus 71 replication through the oxidative stress‑mediated ERS/autophagy pathway
TL;DR: Resveratrol-loaded nanoparticles attenuated EV71‑induced viral replication and inflammatory effects by inhibiting the oxidative stress‑mediated ERS/autophagy signaling pathway and have potential applications in protecting RD cells from EV71 injury.
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Molecular modelling of the antiviral action of Resveratrol derivatives against the activity of two novel SARS CoV-2 and 2019-nCoV receptors.
TL;DR: This work chooses resveratrol (RV) derivatives and two newly released coordinate structures for COVID-19 as receptors and shows that conformational isomerism is significant and useful parameter for docking results, and can provide a fast prediction of the positive influence the targets on the CO VID-19 outbreak.
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Therapeutic Potential of Exploiting Autophagy Cascade Against Coronavirus Infection
Subhajit Maity,Abhik Saha +1 more
TL;DR: In this paper, the authors discuss about the current knowledge linking autophagy to coronaviruses and how that is being utilized to repurpose autophathy modulators as potential COVID-19 treatment.