Modulation of the autophagy pathway by human tumor viruses.
Lindsey Silva,Jae U. Jung +1 more
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TLDR
A comprehensive understanding of the autophagic response to tumor viruses may enable the discovery of novel antiviral and/or anticancer drug therapies.About:
This article is published in Seminars in Cancer Biology.The article was published on 2013-10-01 and is currently open access. It has received 47 citations till now. The article focuses on the topics: Autophagy & Viral life cycle.read more
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Journal ArticleDOI
Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment
TL;DR: New studies indicate that, in addition to its cell-autonomous anti-tumorigenic functions, autophagy inhibits cancer development by orchestrating inflammation and immunity and should improve the efficacy of cancer immunotherapy.
Journal ArticleDOI
Herpes Simplex Virus Type 1 Infection of the Central Nervous System: Insights Into Proposed Interrelationships With Neurodegenerative Disorders.
Luisa F. Duarte,Mónica A. Farías,Diana Alvarez,Susan M. Bueno,Claudia A. Riedel,Pablo A. González +5 more
TL;DR: There is accumulating evidence that suggests that HSV-1 infection of the brain both, in symptomatic and asymptomatic individuals could lead to neuronal damage and eventually, neurodegenerative disorders.
Book ChapterDOI
Autophagy and Viral Infection.
TL;DR: This chapter illustrates how autophagy prevents viral infection to generate an optimal anti-viral milieu, and focuses on how viruses subvert and hijack the autophagic process to evade immunosurveillance, thereby facilitating viral replication and pathogenesis.
Journal ArticleDOI
Kaposi's Sarcoma-Associated Herpesvirus K7 Modulates Rubicon-Mediated Inhibition of Autophagosome Maturation
Qiming Liang,Brian Chang,Kevin Brulois,Kamilah Castro,Chan Ki Min,Mary A. Rodgers,Mude Shi,Jianning Ge,Pinghui Feng,Byung-Ha Oh,Jae U. Jung +10 more
TL;DR: It is reported that K SHV K7 protein interacts with Rubicon autophagy protein and inhibits the autophagosome maturation step by blocking Vps34 enzymatic activity, further highlighting how KSHV deregulates autophagic-mediated host immunity for its life cycle.
Journal ArticleDOI
EBV reduces autophagy, intracellular ROS and mitochondria to impair monocyte survival and differentiation.
M. S. Gilardini Montani,Roberta Santarelli,Marisa Granato,Roberta Gonnella,Maria Rosaria Torrisi,Alberto Faggioni,Mara Cirone +6 more
TL;DR: It is shown for the first time that the interconnected reduction of autophagy, intracellular ROS and mitochondria mediated by EBV switches monocyte differentiation into apoptosis, giving new insights into the mechanisms through which this virus reduces immune surveillance.
References
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Journal ArticleDOI
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
Yukiko Kabeya,Noboru Mizushima,Noboru Mizushima,Takashi Ueno,Akitsugu Yamamoto,Takayoshi Kirisako,Takayoshi Kirisako,Takeshi Noda,Takeshi Noda,Eiki Kominami,Yoshinori Ohsumi,Yoshinori Ohsumi,Tamotsu Yoshimori,Tamotsu Yoshimori +13 more
TL;DR: It is demonstrated that the rat microtubule‐associated protein 1 light chain 3 (LC3), a homologue of Apg8p essential for autophagy in yeast, is associated to the autophagosome membranes after processing.
Journal ArticleDOI
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy.
Sophie Pattingre,Sophie Pattingre,Amina T. Tassa,Xueping Qu,Xueping Qu,Rita Garuti,Xiao Huan Liang,Noboru Mizushima,Milton Packer,Michael D. Schneider,Beth Levine,Beth Levine +11 more
TL;DR: Bcl-2 not only functions as an antiapoptotic protein, but also as an antiautophagy protein via its inhibitory interaction with Beclin 1, which may help maintain autophagy at levels that are compatible with cell survival, rather than cell death.
Journal ArticleDOI
Hepatitis C Virus Infection
Georg M. Lauer,Bruce D. Walker +1 more
TL;DR: The institution of blood-screening measures in developed countries has decreased the risk of transfusion-associated hepatitis to a negligible level, but new cases continue to occur mainly as a result of injection-drug use and, to a lesser degree, through other means of percutaneous or mucous-membrane exposure.
Journal ArticleDOI
Autophagy Is Activated for Cell Survival after Endoplasmic Reticulum Stress
Maiko Ogata,Shin-ichiro Hino,Atsushi Saito,Keisuke Morikawa,Shinichi Kondo,Soshi Kanemoto,Tomohiko Murakami,Manabu Taniguchi,Ichiro Tanii,Kazuya Yoshinaga,Sadao Shiosaka,James A. Hammarback,Fumihiko Urano,Kazunori Imaizumi +13 more
TL;DR: It is found that the autophagy system is activated as a novel signaling pathway in response to ER stress and played important roles in cell survival after ER stress.
Journal ArticleDOI
Towards a systems understanding of MHC class I and MHC class II antigen presentation
TL;DR: A timely evaluation of the biology of antigen presentation and a survey of issues that are considered unresolved are presented.