Targeting autophagy with natural products to prevent SARS-CoV-2 infection.
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TLDR
In this paper, natural products capable of interfering with SARS-CoV-2 cellular infection and replication through their action on autophagy have been reported as adjuvant therapeutics for the management of COVID-19 pandemic.About:
This article is published in Journal of Traditional and Complementary Medicine.The article was published on 2021-10-14 and is currently open access. It has received 10 citations till now. The article focuses on the topics: Autophagy & Biology.read more
Citations
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Journal ArticleDOI
Computational studies on the interaction of SARS-CoV-2 Omicron SGp RBD with human receptor ACE2, limonin and glycyrrhizic acid
Seshu Vardhan,Suban K. Sahoo +1 more
TL;DR: In this article , the interactions of SARS-CoV-2 spike glycoprotein receptor-binding domain (SGp RBD) of the three variants (Omicron, Delta, and WT) with the receptor hACE2.1.
Journal ArticleDOI
Exosomes, autophagy and ER stress pathways in human diseases: Cross-regulation and therapeutic approaches.
Babak Jahangiri,Ali Kian Saei,Patience O. Obi,Narjes Asghari,Shahrokh Lorzadeh,Shirin Hekmatirad,Marveh Rahmati,Fatemeh Velayatipour,Mohammad Hossein Asghari,Ayesha Saleem,Mohammad Amin Moosavi +10 more
TL;DR: In this paper , the authors review the available information on the mechanisms that control autophagy, ER stress and EV pathways, with the view that a better understanding of their crosstalk and balance may improve our knowledge on the pathogenesis and treatment of human diseases, where these pathways are dysregulated.
Journal ArticleDOI
Further quantitative in silico analysis of SARS-CoV-2 S-RBD Omicron BA.4, BA.5, BA.2.75, BQ.1, and BQ.1.1 transmissibility
TL;DR: In this paper , the Covid-19 variants' transmissibility was further quantitatively analyzed in silico to study the binding strength with ACE-2 and find the binding inhibitors.
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Recent Progress in the Development of Opaganib for the Treatment of Covid-19
TL;DR: In this article , a tripartite model by which opaganib suppresses infection and replication of SARS-CoV-2 by inhibiting SK2, DES1 and GCS was presented.
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Wheat Germ Spermidine and Clove Eugenol in Combination Stimulate Autophagy In Vitro Showing Potential in Supporting the Immune System against Viral Infections
Francesca Truzzi,Anne Whittaker,Eros D'Amen,Camilla Tibaldi,A. Abate,Maria Chiara Valerii,Enzo Spisni,Giovanni Dinelli +7 more
TL;DR: Comparable benefits of SPD, EUG and SPD + EUG in inducing autophagy and reducing inflammation in vitro and could show promise for COVID-19 risk groups are shown.
References
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Double-Membrane Vesicles as Platforms for Viral Replication.
TL;DR: In this article, the authors review contemporary understanding of the biogenesis, structure, and function of virus-induced double-membrane vesicles (DMVs) as well as the open questions posed by these intriguing structures.
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Targeting SARS-CoV-2 spike protein of COVID-19 with naturally occurring phytochemicals: an in silico study for drug development.
Preeti Pandey,Jitendra Subhash Rane,Aroni Chatterjee,Abhijeet Kumar,Rajni Khan,Amresh Prakash,Shashikant Ray +6 more
TL;DR: Molecular docking studies using 10 potential naturally occurring compounds against the SARS-CoV-2 spike protein and compared their affinity with an FDA approved repurposed drug hydroxychloroquine revealed that these molecules bind with the hACE2-S complex with low binding free energy, and ADME analysis suggested that they consist of drug-likeness property, which may be further explored as anti-SARS- CoV- 2 agents.
Journal ArticleDOI
Viruses and the autophagy pathway.
TL;DR: The goal of this review is to summarize, in brief, what the authors know so far about the relationship between autophagy and viruses, particularly for those who are not familiar with the field.
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Essential Oils as Antiviral Agents. Potential of Essential Oils to Treat SARS-CoV-2 Infection: An In-Silico Investigation.
TL;DR: The docking energies of essential oil components with SARS-CoV-2 targets were relatively weak compared to docking energies with other proteins and are, therefore, unlikely to interact with the virus targets.
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Molecular docking study of potential phytochemicals and their effects on the complex of SARS-CoV2 spike protein and human ACE2.
TL;DR: Five phytochemicals, which belong to flavonoid and anthraquinone subclass, have been selected as small molecules in molecular docking study of spike protein of SARS-CoV2 with its human receptor ACE2 molecule and their molecular binding sites on spike protein bound structure with its receptor have been analyzed.