Journal ArticleDOI
The A1 allele of the DRD2 gene (TaqI A polymorphisms) is associated with antisocial personality in a sample of alcohol-dependent patients.
Guillermo Ponce,Miguel Ángel Jiménez-Arriero,Gabriel Rubio,Janet Hoenicka,Israel Ampuero,J.A. Ramos,Tomás Palomo +6 more
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TLDR
The results support the existence of an association between the A1 allele and factors resulting from dopaminergic deficiency, otherwise denominated reward deficiency syndrome.About:
This article is published in European Psychiatry.The article was published on 2003-11-01. It has received 104 citations till now. The article focuses on the topics: Alcohol dependence & Alcohol use disorder.read more
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Are Political Orientations Genetically Transmitted
TL;DR: The authors combine relevant findings in behavioral genetics with their own analysis of data on a large sample of twins to test the hypothesis that, contrary to the assumptions embedded in political science research, political attitudes have genetic as well as environmental causes.
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A neurobehavioral model of affiliative bonding: Implications for conceptualizing a human trait of affiliation.
TL;DR: It is proposed that the capacity to experience affiliative reward via opiate functioning has a disproportionate weight in determining individual differences in affiliation.
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Substance use disorders: Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM‐IV) and International Classification of Diseases, tenth edition (ICD‐10)
TL;DR: Dependence in DSM-V and ICD-11 should be retained, standardizing both criteria sets and adding a severity measure, and reliability and psychometric validity evidence for substance dependence is consistently strong, but more mixed for abuse and harmful use.
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Elucidating the etiology of individual differences in parenting: A meta-analysis of behavioral genetic research.
TL;DR: Results reveal significant effects of parental genetic makeup on parental behavior, but also highlight the genetic makeup of the child as a particularly prominent source of genetic transmission (via evocative gene-environment correlation).
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Correlated genotypes in friendship networks
TL;DR: The results suggest that association tests should include friends’ genes and that theories of evolution should take into account the fact that humans might, in some sense, be metagenomic with respect to the humans around them.
References
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Journal ArticleDOI
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
G. Di Chiara,Assunta Imperato +1 more
TL;DR: The effect of various drugs on the extracellular concentration of dopamine in two terminal dopaminergic areas, the nucleus accumbens septi (a limbic area) and the dorsal caudate nucleus (a subcortical motor area), was studied in freely moving rats by using brain dialysis as mentioned in this paper.
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An improved diagnostic evaluation instrument for substance abuse patients. The Addiction Severity Index.
TL;DR: The use of the ASI is suggested to match patients with treatments and to promote greater comparability of research findings, suggesting the treatment problems of patients are not necessarily related to the severity of their chemical abuse.
Journal ArticleDOI
Cellular and molecular mechanisms of drug dependence.
George F. Koob,Floyd E. Bloom +1 more
TL;DR: The molecular and cellular actions of three classes of abused drugs--opiates, psychostimulants, and ethanol--are reviewed in the context of behavioral studies of drug dependence.
Journal ArticleDOI
Neuroscience of Addiction
TL;DR: This is publication number 11130-NP from The Scripps Research Institute and research was supported by National Institutes of Health grants DA04043, DA04398, and DA08467.
Journal ArticleDOI
Allelic association of human dopamine D2 receptor gene in alcoholism.
Kenneth Blum,Ernest P. Noble,Peter J. Sheridan,Anne Montgomery,Terry Ritchie,Pudur Jagadeeswaran,Harou Nogami,Arthur H. Briggs,Jay B. Cohn +8 more
TL;DR: The polymorphic pattern of this receptor gene suggests that a gene that confers susceptibility to at least one form of alcoholism is located on the q22-q23 region of chromosome 11.