Journal ArticleDOI
The anti-death machinery in IKK/NF-kappaB signaling.
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TLDR
Intervention of IKK/NF-κB signaling would be a promising option to improve the efficacy of cancer treatment and help tumor cells to escape the killing of conventional anti-cancer therapies.Abstract:
The most extensively studied function of NF-kappaB is its ability to promote cell survival through induction of target genes, whose products inhibit various aspects of the apoptotic machinery in both normal and malignant cells. Recent studies, however, indicate that NF-kappaB activation can also suppress programmed necrosis through induction of genes encoding anti-oxidant proteins. Since tumor cells often use NF-kappaB pathway as a shield to escape the killing of conventional anti-cancer therapies, intervention of IKK/NF-kappaB signaling would be a promising option to improve the efficacy of cancer treatment.read more
Citations
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Journal ArticleDOI
NF-κB, inflammation, and metabolic disease.
TL;DR: It is now widely appreciated that chronic low-grade inflammation plays a key role in the initiation, propagation, and development of metabolic diseases, and numerous recent studies have implicated the transcription factor NF-κB in the development of such diseases, thereby further establishing inflammation as a critical factor in their etiology.
Journal ArticleDOI
Is NF-κB a good target for cancer therapy? Hopes and pitfalls
Véronique Baud,Michael Karin +1 more
TL;DR: Recent evidence from cancer genetics and cancer genome studies that support the involvement of NF-κB in human cancer, particularly in multiple myeloma are discussed.
Journal ArticleDOI
Current insights into the regulation of programmed cell death by NF-kappaB.
TL;DR: There has been substantial progress in understanding NF-κB's mode of action in apoptosis and necrosis and the mechanisms that regulate its anti- vs proapoptotic activities, and recent developments shed new light on the role of NF-KappaB in many disease conditions including tumor development, tumor progression and anticancer treatment.
Journal ArticleDOI
Neuroinflammation and Cerebrovascular Disease in Old Age: A Translational Medicine Perspective
Mario Di Napoli,Imtiaz M. Shah +1 more
TL;DR: Molecular aspects of acute stroke and senescence from a bench-to-bedside research perspective are discussed and inflammatory pathways and oxidative stress remain attractive therapeutic targets for the development of adjuvant neuroprotective agents.
Journal ArticleDOI
Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor–induced toxicity and experimental colitis
Lars Vereecke,Mozes Sze,Conor Mc Guire,Brecht Rogiers,Yuanyuan Chu,Marc Schmidt-Supprian,Manolis Pasparakis,Rudi Beyaert,Geert van Loo +8 more
TL;DR: A20 is defined as a major antiapoptotic protein in the intestinal epithelium and further indicate that defects in A20 might contribute to inflammatory bowel disease in humans.
References
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Journal ArticleDOI
Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.
TL;DR: Apoptosis seems to be involved in cell turnover in many healthy adult tissues and is responsible for focal elimination of cells during normal embryonic development, and participates in at least some types of therapeutically induced tumour regression.
Book ChapterDOI
Cell death : the significance of apoptosis
TL;DR: It has proved feasible to categorize most if not all dying cells into one or the other of two discrete and distinctive patterns of morphological change, which have, generally, been found to occur under disparate but individually characteristic circumstances.
Journal ArticleDOI
The biochemistry of apoptosis
TL;DR: The basic components of the death machinery are reviewed, how they interact to regulate apoptosis in a coordinated manner is described, and the main pathways that are used to activate cell death are discussed.
Journal ArticleDOI
Mammalian MAP kinase signalling cascades
Lufen Chang,Michael Karin +1 more
TL;DR: Recent studies have begun to shed light on the physiological functions of MAPK cascades in the control of gene expression, cell proliferation and programmed cell death.
Journal ArticleDOI
Cell Death: Critical Control Points
TL;DR: The identification of critical control points in the cell death pathway has yielded fundamental insights for basic biology, as well as provided rational targets for new therapeutics.
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NF-kappaB: linking inflammation and immunity to cancer development and progression.
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