Journal ArticleDOI
The effect of intranasal administration of oxytocin on fear recognition.
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TLDR
A single intranasal administration of oxytocin, as opposed to the placebo, improved the subjects' ability to recognize fear, but not other emotions, suggesting a specific role for oxytoc in fear recognition, which could be relevant for clinical disorders that manifest deficits in processing emotional facial expressions, particularly fear.About:
This article is published in Neuropsychologia.The article was published on 2010-01-01. It has received 180 citations till now. The article focuses on the topics: Oxytocin.read more
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Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
TL;DR: OXT and AVP are emerging as targets for novel treatment approaches — particularly in synergistic combination with psychotherapy — for mental disorders characterized by social dysfunction, such as autism, social anxiety disorder, borderline personality disorder and schizophrenia.
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The peptide that binds: a systematic review of oxytocin and its prosocial effects in humans.
TL;DR: Key conclusions are (1) human research with intranasal oxytocin has uniquely enhanced the authors' understanding of the microstructure and function of the human social brain, and (2) the Oxytocin system is a promising target for therapeutic interventions in a variety of conditions, especially those characterized by anxiety and aberrations in social function.
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Different amygdala subregions mediate valence-related and attentional effects of oxytocin in humans.
TL;DR: Different behavioral effects of oxytocin seem to be closely related its specific modulatory influence on subregions within the human amygdala.
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Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder.
Izelle Labuschagne,K. Luan Phan,Amanda G. Wood,Mike Angstadt,Phyllis Chua,Markus Heinrichs,Julie C. Stout,Pradeep J. Nathan,Pradeep J. Nathan +8 more
TL;DR: It is suggested that OXT has a specific effect on fear-related amygdala activity, particularly when the amygdala is hyperactive, such as in GSAD, thereby providing a brain-based mechanism of the impact of OXT in modulating the exaggerated processing of social signals of threat in patients with pathological anxiety.
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Acute effects of steroid hormones and neuropeptides on human social–emotional behavior: A review of single administration studies
TL;DR: All placebo-controlled single hormone administration studies addressing human social-emotional behavior, involving the steroids testosterone and estradiol, and the peptides oxytocin and vasopressin are reviewed and a theoretical model is proposed that synthesizes detailed knowledge of the neuroendocrinology of social- Emotional behavior in animals with the recently gained data from humans.
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Functional neuroanatomy of emotion: a meta-analysis of emotion activation studies in PET and fMRI.
TL;DR: A critical comparison of findings across individual studies is provided and suggests that separate brain regions are involved in different aspects of emotion.
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Oxytocin increases trust in humans
TL;DR: It is shown that intranasal administration of oxytocin, a neuropeptide that plays a key role in social attachment and affiliation in non-human mammals, causes a substantial increase in trust among humans, thereby greatly increasing the benefits from social interactions.
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Masked Presentations of Emotional Facial Expressions Modulate Amygdala Activity without Explicit Knowledge
Paul J. Whalen,Scott L. Rauch,Nancy L. Etcoff,Sean C. McInerney,Michael B. Lee,Michael A. Jenike +5 more
TL;DR: This study, using fMRI in conjunction with masked stimulus presentations, represents an initial step toward determining the role of the amygdala in nonconscious processing.
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Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala.
Ralph Adolphs,Daniel Tranel,Hanna Damasio,Hanna Damasio,Antonio R. Damasio,Antonio R. Damasio +5 more
TL;DR: Findings suggest the human amygdala may be indispensable to recognize fear in facial expressions, but is not required to recognize personal identity from faces, and constrains the broad notion that the amygdala is involved in emotion.