The extracellular matrix in myocardial injury, repair, and remodeling
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TLDR
The role of the ECM in cardiac repair and remodeling is reviewed and matrix-based therapies that may attenuate remodeling while promoting repair and regeneration are discussed.Abstract:
The cardiac extracellular matrix (ECM) not only provides mechanical support, but also transduces essential molecular signals in health and disease. Following myocardial infarction, dynamic ECM changes drive inflammation and repair. Early generation of bioactive matrix fragments activates proinflammatory signaling. The formation of a highly plastic provisional matrix facilitates leukocyte infiltration and activates infarct myofibroblasts. Deposition of matricellular proteins modulates growth factor signaling and contributes to the spatial and temporal regulation of the reparative response. Mechanical stress due to pressure and volume overload and metabolic dysfunction also induce profound changes in ECM composition that contribute to the pathogenesis of heart failure. This manuscript reviews the role of the ECM in cardiac repair and remodeling and discusses matrix-based therapies that may attenuate remodeling while promoting repair and regeneration.read more
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Book ChapterDOI
Engineered cardiac tissue: Concepts and future
Soumya K. Chandrasekhar,Soumya K. Chandrasekhar,Finosh G. Thankam,Joshi C. Ouseph,Devendra K. Agrawal +4 more
TL;DR: The chapter portrays the promise of next generation regenerative cardiology which gives pleasant hope for the millions of CVD sufferers throughout the globe.
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Identification of Hub Genes in the Remodeling of Non-Infarcted Myocardium Following Acute Myocardial Infarction
TL;DR: In this article , the authors identified 10 strongly interlinked hub genes (Timp1, Sparc, Spp1, Tgfb1, Decr1, Vim, Serpine1, Serpina3n, Thbs2, and Vcan) by the construction of a protein-protein interaction network.
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Identification of potential dilated cardiomyopathy-related targets by meta-analysis and co-expression analysis of human RNA-sequencing datasets.
Zixun Yuan,Nobuyuki Murakoshi,Dongzhu Xu,Kazuko Tajiri,Yuta Okabe,Kazuhiro Aonuma,Yoshiko Murakata,Siqi Li,Zong-En Song,Yuzuno Shimoda,Haruka Mori,Kazutaka Aonuma,Masaki Ieda +12 more
TL;DR: Wang et al. as discussed by the authors performed meta-analysis and co-expression analysis of RNA-sequencing (RNA-seq) datasets from publicly available databases and extracted differentially expressed genes (DEGs) and clarified upstream regulators of cardiovascular disease-related DEGs.
Journal ArticleDOI
Construction of a myocardial patch with mesenchymal stem cells and poly(CL-co-TOSUO)/collagen scaffolds for myocardial infarction repair by coaxial electrospinning.
TL;DR: In this paper , a novel and multifunctional stem cell patch with favorable mechanical properties was reported, and the scaffold was prepared by coaxial electrospinning of poly (CL-co-TOSUO)/collagen (PCT/collagen) core/shell nanofibers.
Book ChapterDOI
Myocardial tissue engineering: Fundamentals and future
TL;DR: In this paper , the authors provide insights into the fundamental principles and practices in cardiac tissue engineering along with a futuristic outlook, and a review of the current state of the art in CTE.
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