The extracellular matrix in myocardial injury, repair, and remodeling
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TLDR
The role of the ECM in cardiac repair and remodeling is reviewed and matrix-based therapies that may attenuate remodeling while promoting repair and regeneration are discussed.Abstract:
The cardiac extracellular matrix (ECM) not only provides mechanical support, but also transduces essential molecular signals in health and disease. Following myocardial infarction, dynamic ECM changes drive inflammation and repair. Early generation of bioactive matrix fragments activates proinflammatory signaling. The formation of a highly plastic provisional matrix facilitates leukocyte infiltration and activates infarct myofibroblasts. Deposition of matricellular proteins modulates growth factor signaling and contributes to the spatial and temporal regulation of the reparative response. Mechanical stress due to pressure and volume overload and metabolic dysfunction also induce profound changes in ECM composition that contribute to the pathogenesis of heart failure. This manuscript reviews the role of the ECM in cardiac repair and remodeling and discusses matrix-based therapies that may attenuate remodeling while promoting repair and regeneration.read more
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Dual versus single energy cardiac CT to measure extra cellular volume in cardiac amyloidosis: Correlations with cardiac MRI
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Interstitial changes after reperfused myocardial infarction in swine: morphometric and genetic analysis
Cesar Rios-Navarro,María Elena Olmos Ortega,Víctor Marcos-Garcés,Jose Gavara,Elena de Dios,Nerea Perez-Sole,Francisco J. Chorro,Vicente Bodi,Amparo Ruiz-Sauri +8 more
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Transplantation of Skeletal Muscle-Derived Sca-1+/PW1+/Pax7− Interstitial Cells (PICs) Improves Cardiac Function and Attenuates Remodeling in Mice Subjected to Myocardial Infarction
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TL;DR: In this paper , skeletal muscle-derived interstitial cells (PICs) were used for intramyocardial transplantation in mice subjected to an acute myocardial infarction.
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