The neuroscience of placebo effects: connecting context, learning and health
Tor D. Wager,Lauren Y. Atlas +1 more
TLDR
An empirical review of the brain systems that are involved in placebo effects and a conceptual framework linking these findings to the mind–brain processes that mediate them suggest that the neuropsychological processes thatMediate placebo effects may be crucial for a wide array of therapeutic approaches, including many drugs.Abstract:
Placebo effects are positive effects on health that arise from the response of the brain to the contextual information that accompanies the delivery of a treatment. In this Review, Wager and Atlas examine the neural mechanisms that underlie such effects, focusing on placebo analgesia.read more
Citations
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Optimizing performance through intrinsic motivation and attention for learning: The OPTIMAL theory of motor learning
Gabriele Wulf,Rebecca Lewthwaite +1 more
TL;DR: The OPTIMAL (Optimizing Performance through Intrinsic Motivation and Attention for Learning) theory of motor learning is proposed, suggesting that motivational and attentional factors contribute to performance and learning by strengthening the coupling of goals to actions.
Journal ArticleDOI
Open-label placebo treatment in chronic low back pain: a randomized controlled trial
Claudia M.B. Carvalho,Joaquim António Machado Caetano,Lidia Cunha,Paula Rebouta,Ted J. Kaptchuk,Irving Kirsch +5 more
TL;DR: The findings suggest that OLP pills presented in a positive context may be helpful in chronic low back pain.
Journal ArticleDOI
Explicit and implicit emotion regulation: a multi-level framework
TL;DR: The utility of a framework that distinguishes among four fundamental classes of emotion regulation strategies is explored, which is used to review human and animal research on the neural bases of emotionregulation and to suggest key directions for future research on emotion regulation.
Journal ArticleDOI
Implications of Placebo and Nocebo Effects for Clinical Practice: Expert Consensus.
Andrea W M Evers,Luana Colloca,Charlotte Blease,Marco Annoni,Lauren Y. Atlas,Fabrizio Benedetti,Ulrike Bingel,Christian Büchel,Claudia M.B. Carvalho,Ben Colagiuri,Alia J. Crum,Paul Enck,Jens Gaab,Andrew L. Geers,Jeremy Howick,Karin B. Jensen,Irving Kirsch,Karin Meissner,Vitaly Napadow,Kaya J. Peerdeman,Amir Raz,Winfried Rief,Lene Vase,Tor D. Wager,Bruce E. Wampold,Katja Weimer,Katja Wiech,Ted J. Kaptchuk,Regine Klinger,John M. Kelley +29 more
TL;DR: This paper forms a first step towards developing evidence-based and ethical recommendations about the implications of placebo and nocebo research for medical practice, based on the current state of evidence and the consensus of experts.
References
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Book
Judgment Under Uncertainty: Heuristics and Biases
Amos Tversky,Daniel Kahneman +1 more
TL;DR: The authors described three heuristics that are employed in making judgements under uncertainty: representativeness, availability of instances or scenarios, and adjustment from an anchor, which is usually employed in numerical prediction when a relevant value is available.
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A Neural Substrate of Prediction and Reward
TL;DR: Findings in this work indicate that dopaminergic neurons in the primate whose fluctuating output apparently signals changes or errors in the predictions of future salient and rewarding events can be understood through quantitative theories of adaptive optimizing control.
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What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
TL;DR: It is suggested that dopamine may be more important to incentive salience attributions to the neural representations of reward-related stimuli and is a distinct component of motivation and reward.
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On the social psychology of the psychological experiment: With particular reference to demand characteristics and their implications.
TL;DR: In this paper, the authors focus on some of the qualities peculiar to psychological experiments and point out that the demand characteristics perceived in any particular experiment will vary with the sophistication, intelligence, and previous experience of each experimental subject.
Journal ArticleDOI
Deep brain stimulation for treatment-resistant depression.
Helen S. Mayberg,Helen S. Mayberg,Andres M. Lozano,Valerie Voon,Heather E. McNeely,David A. Seminowicz,Clement Hamani,Jason M. Schwalb,Sidney H. Kennedy +8 more
TL;DR: It is suggested that disrupting focal pathological activity in limbic-cortical circuits using electrical stimulation of the subgenual cingulate white matter can effectively reverse symptoms in otherwise treatment-resistant depression.