Journal ArticleDOI
The NLRP3 inflammasome inhibitor, OLT1177® , ameliorates experimental allergic asthma in mice.
Lars Lunding,Damaris B. Skouras,Christina Vock,Charles A. Dinarello,Charles A. Dinarello,Michael Wegmann +5 more
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This article is published in Allergy.The article was published on 2021-10-30. It has received 11 citations till now. The article focuses on the topics: Inflammasome.read more
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Adipose Tissue Inflammation and Pulmonary Dysfunction in Obesity
Giuseppe De Palma,Gian Pio Sorice,Valentina Annamaria Genchi,Fiorella Giordano,Cristina Caccioppoli,Rossella Doria,Nicola Marrano,Giuseppina Biondi,Francesco Giorgino,Sebastio Perrini +9 more
TL;DR: This review will investigate the crosstalk between adipose tissue and the lung in obesity, highlighting the main inflammatory mediators and novel therapeutic targets in preventing pulmonary dysfunction.
Journal ArticleDOI
The NLRP3 inflammasome as a new target in respiratory disorders treatment
TL;DR: The novelty of recent years has been the association between NLRP3 inflammasome activation and the development of airway inflammatory diseases, and this seems to be an interesting therapeutic target that may support or even replace traditional therapies in the future.
Journal ArticleDOI
IL-36 Cytokines: Their Roles in Asthma and Potential as a Therapeutic
TL;DR: The present study provides a summary of recent reports on IL-36 cytokines that participate in the pathogenesis of inflammatory diseases, and the potential mechanisms underlying their roles in asthma, and suggests these may become a potential therapeutic target for asthma treatment.
Journal ArticleDOI
Carbenoxolone ameliorates allergic airway inflammation through NF-κB/NLRP3 pathway in mice.
TL;DR: The results showed that CBX can significantly attenuate the leukocyte count and the percentage of eosinophils and neutrophils in the BALF, peribronchial inflammation, airway mucus secretion, collagen deposition area, and AR in OVA-induced airway inflammation.
Journal ArticleDOI
Involvement of inflammasomes in tumor microenvironment and tumor therapies
TL;DR: In this article , the activation of inflammasomes is regulated at both transcription and posttranscription levels, which is crucial in protecting the host from infections and sterile insults, implying an important link between inflammation and tumor development.
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Journal ArticleDOI
OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.
Carlo Marchetti,Benjamin J Swartzwelter,Fabia Gamboni,Charles Preston Neff,Katrin Richter,Tania Azam,Sonia Carta,Isak W. Tengesdal,Travis Nemkov,Angelo D'Alessandro,Curtis J. Henry,Gerald S. Jones,Scott A. Goodrich,Joseph P. St. Laurent,Terry M. Jones,Curtis L. Scribner,Robert B. Barrow,Roy D. Altman,Damaris B. Skouras,Marco Gattorno,Veronika Grau,Sabina Janciauskiene,Anna Rubartelli,Leo A. B. Joosten,Charles A. Dinarello,Charles A. Dinarello +25 more
TL;DR: It is demonstrated that OLT1177, an orally active β-sulfonyl nitrile molecule, inhibits activation of the NLRP3 inflammasome, with unique properties to reverse the metabolic costs of inflammation and to treat IL-1β– and IL-18–mediated diseases.
Journal ArticleDOI
Dapansutrile, an oral selective NLRP3 inflammasome inhibitor, for treatment of gout flares: an open-label, dose-adaptive, proof-of-concept, phase 2a trial
Viola Klück,T.L.Th.A. Jansen,Matthijs Janssen,Antoaneta Comarniceanu,M. Efde,Isak W. Tengesdal,Kiki Schraa,Maartje C. P. Cleophas,Curtis L. Scribner,Damaris B. Skouras,Carlo Marchetti,Charles A. Dinarello,Charles A. Dinarello,Leo A. B. Joosten,Leo A. B. Joosten +14 more
TL;DR: Dapansutrile is a specific NLRP3 inflammasome inhibitor with a satisfactory safety profile and efficacy in the reduction of target joint pain in this study.
Journal ArticleDOI
Advances and recent developments in asthma in 2020.
Lacin Cevhertas,Lacin Cevhertas,Ismail Ogulur,Ismail Ogulur,Debbie J Maurer,Daniel Burla,Mei Ding,Mei Ding,Kirstin Jansen,Jana Koch,Chengyao Liu,Siyuan Ma,Yasutaka Mitamura,Yaqi Peng,Urszula Radzikowska,Urszula Radzikowska,Arturo Rinaldi,Pattraporn Satitsuksanoa,Anna Głobińska,Willem van de Veen,Milena Sokolowska,Katja Baerenfaller,Ya-dong Gao,Ioana Agache,Mübeccel Akdis,Cezmi A. Akdis +25 more
TL;DR: The most relevant experimental studies further advancing the understanding of molecular and immune mechanisms with potential new targets for the development of therapeutics are discussed and critical approaches and strategies in asthma treatment linked to mechanisms and endotypes of asthma, particularly biologicals are critically appraised.
Journal ArticleDOI
The NLRP3 inflammasome: role in airway inflammation
H. Im,Alaina J. Ammit +1 more
TL;DR: The structure and function of the inflammasome is described and an overview of the current understanding of role of theInflammasomes in airway inflammation is provided, focusing on nucleotide‐binding domain and leucine‐rich repeat protein 3 (NLRP3) inflammaome as it is the best‐characterized subtype shown expressed inAirway and considered to play a key role in chronic airway diseases such as asthma.
Journal ArticleDOI
Phase 1B, Randomized, Double-Blinded, Dose Escalation, Single-Center, Repeat Dose Safety and Pharmacodynamics Study of the Oral NLRP3 Inhibitor Dapansutrile in Subjects With NYHA II-III Systolic Heart Failure.
George F. Wohlford,Benjamin W. Van Tassell,Hayley Billingsley,Dinesh Kadariya,Justin M. Canada,Salvatore Carbone,Virginia L. Mihalick,Aldo Bonaventura,Alessandra Vecchié,Juan Guido Chiabrando,Edoardo Bressi,Georgia K. Thomas,Ai-Chen Ho,Amr Marawan,Megan Dell,Cory R. Trankle,Jeremy Turlington,Roshanak Markley,Antonio Abbate +18 more
TL;DR: This research presents a novel probabilistic approach that allows us to assess the importance of knowing the carrier and removal status of canine coronavirus as a source of infection in animals and its role in the immune system is investigated.