Open AccessJournal Article
The nuclear epidermal growth factor receptor signaling network and its role in cancer
TLDR
The current knowledge of the nuclear EGFR signaling network is summarized, including how it is trafficked to the nucleus, the functions it serves inThe nucleus, and how these functions impact cancer progression, survival, and response to chemotherapeutics.Abstract:
The epidermal growth factor receptor (EGFR) is a member of the EGFR family of receptor tyrosine kinases (RTKs). EGFR activation via ligand binding results in signaling through various pathways ultimately resulting in cellular proliferation, survival, angiogenesis, invasion, and metastasis. Aberrant expression or activity of EGFR has been strongly linked to the etiology of several human epithelial cancers including but not limited to head and neck squamous cell carcinoma (HNSCC), non-small cell lung cancer (NSCLC), colorectal cancer (CRC), breast cancer, pancreatic cancer, and brain cancer. Thus intense efforts have been made to inhibit the activity of EGFR by designing antibodies against the ligand binding domains (cetuximab and panitumumab) or small molecules against the tyrosine kinase domain (erlotinib, gefitinib, and lapatinib). Although targeting membrane-bound EGFR has shown benefit, a new and emerging role for EGFR is now being elucidated. In this review we will summarize the current knowledge of the nuclear EGFR signaling network, including how it is trafficked to the nucleus, the functions it serves in the nucleus, and how these functions impact cancer progression, survival, and response to chemotherapeutics.read more
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Assessing the role of the EGF receptor in the development and progression of pancreatic cancer
TL;DR: This work is distributed under the terms of the License http://creativecommons.org/licenses/by-nc/3.0/.
Journal ArticleDOI
Epidermal growth factor (EGF) triggers nuclear calcium signaling through the intranuclear phospholipase Cδ-4 (PLCδ4)
Marcelo Coutinho de Miranda,Marcelo Coutinho de Miranda,Michele Angela Rodrigues,Michele Angela Rodrigues,Ana Carolina de Angelis Campos,Ana Carolina de Angelis Campos,Jerusa Araújo Quintão Arantes Faria,Marianna Kunrath-Lima,Gregory A. Mignery,Deborah Schechtman,Alfredo M. Goes,Michael H. Nathanson,Dawidson Assis Gomes,Dawidson Assis Gomes +13 more
TL;DR: Investigation of the role of PLCδ4 in epidermal growth factor (EGF)-induced nuclear Ca2+ signaling and downstream events finds that EGF-induced Ca2+, signals are inhibited when translocation of EGFR is impaired and suggests new therapeutic targets to modulate the proliferative effects of this growth factor.
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IgE-based Immunotherapy of Cancer -A Comparative Oncology Approach.
TL;DR: The benefits and difficulties of IgE-based immunotherapy of cancer are discussed, with special emphasis on how to translate promising preclinical results into clinical studies.
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Expression of vascular endothelial growth factor and epidermal growth factor receptor in pancreatic ductal adenocarcinomas, neuroendocrine tumours and chronic pancreatitis
Radu Angelescu,Florin Burada,Cristina Angelescu,Dan Ionut Gheonea,Sevastita Iordache,Francisc Mixich,Mihai Ioana,Adrian Saftoiu +7 more
TL;DR: Both VEGF and EGFR mRNA expression in EUS-FNA samples may be used as a diagnostic marker associated with invasiveness in patients with pancreatic adenocarcinoma.
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FGF1 protects neuroblastoma SH-SY5Y cells from p53-dependent apoptosis through an intracrine pathway regulated by FGF1 phosphorylation.
Caroline Pirou,Fatemeh Montazer-Torbati,N. Jah,Elisabeth Delmas,Christelle Lasbleiz,Bernard Mignotte,Flore Renaud +6 more
TL;DR: This study provides the first evidence for a role of an intracrine growth factor pathway on p53-dependent apoptosis in neuroblastoma, and could lead to the identification of key regulators involved in Neuroblastoma tumor progression and chemoresistance.
References
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Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
Therese Sørlie,Charles M. Perou,Robert Tibshirani,Turid Aas,Stephanie Geisler,Hilde Johnsen,Trevor Hastie,Michael B. Eisen,Matt van de Rijn,Stefanie S. Jeffrey,T. Thorsen,Hanne Quist,John C. Matese,Patrick O. Brown,David Botstein,Per Eystein Lønning,Anne Lise Børresen-Dale +16 more
TL;DR: Survival analyses on a subcohort of patients with locally advanced breast cancer uniformly treated in a prospective study showed significantly different outcomes for the patients belonging to the various groups, including a poor prognosis for the basal-like subtype and a significant difference in outcome for the two estrogen receptor-positive groups.
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Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
Axel Ullrich,Lisa M. Coussens,Joel S. Hayflick,Thomas J. Dull,Alane M. Gray,A W Tam,Jeffrey E. Lee,Yosef Yarden,Towia A. Libermann,Joseph Schlessinger +9 more
TL;DR: The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) receptor precursor, deduced from cDNA clones derived from placental and A431 carcinoma cells, reveals close similarity between the entire predicted ν-erb-B mRNA oncogene product and the receptor transmembrane and cytoplasmic domains.
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Immunohistochemical and Clinical Characterization of the Basal-Like Subtype of Invasive Breast Carcinoma
Torsten O. Nielsen,Forrest D. Hsu,Kristin C. Jensen,Maggie C.U. Cheang,Gamze Karaca,Zhiyuan Hu,Tina Hernandez-Boussard,Chad A. Livasy,Dave Cowan,Lynn G. Dressler,Lars A. Akslen,Joseph Ragaz,Allen M. Gown,C. Blake Gilks,Matt van de Rijn,Charles M. Perou +15 more
TL;DR: A panel of four antibodies (ER, HER1, HER2, and cytokeratin 5/6) can accurately identify basal-like tumors using standard available clinical tools and shows high specificity.
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Isolation of a Mouse Submaxillary Gland Protein Accelerating Incisor Eruption and Eyelid Opening in the New-born Animal
TL;DR: The isolation of the factor responsible for the earlier development of the incisors and eyelids is reported here, a heat-stable, nondialysable, antigenic protein, whose most distinctive chemical characteristic is the absence of phenylalanine and lysine.
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Nuclear localization of EGF receptor and its potential new role as a transcription factor
Shiaw Yih Lin,Keishi Makino,Weiya Xia,Angabin Matin,Yong Wen,Ka Yin Kwong,Lilly Y.W. Bourguignon,Mien Chie Hung +7 more
TL;DR: It is demonstrated that nuclear EGFR is strongly correlated with highly proliferating activities of tissues and associated with promoter region of cyclin D1 in vivo, suggesting that EGFR might function as a transcription factor to activate genes required for highly proliferationating activities.