Open AccessJournal Article
The nuclear epidermal growth factor receptor signaling network and its role in cancer
TLDR
The current knowledge of the nuclear EGFR signaling network is summarized, including how it is trafficked to the nucleus, the functions it serves inThe nucleus, and how these functions impact cancer progression, survival, and response to chemotherapeutics.Abstract:
The epidermal growth factor receptor (EGFR) is a member of the EGFR family of receptor tyrosine kinases (RTKs). EGFR activation via ligand binding results in signaling through various pathways ultimately resulting in cellular proliferation, survival, angiogenesis, invasion, and metastasis. Aberrant expression or activity of EGFR has been strongly linked to the etiology of several human epithelial cancers including but not limited to head and neck squamous cell carcinoma (HNSCC), non-small cell lung cancer (NSCLC), colorectal cancer (CRC), breast cancer, pancreatic cancer, and brain cancer. Thus intense efforts have been made to inhibit the activity of EGFR by designing antibodies against the ligand binding domains (cetuximab and panitumumab) or small molecules against the tyrosine kinase domain (erlotinib, gefitinib, and lapatinib). Although targeting membrane-bound EGFR has shown benefit, a new and emerging role for EGFR is now being elucidated. In this review we will summarize the current knowledge of the nuclear EGFR signaling network, including how it is trafficked to the nucleus, the functions it serves in the nucleus, and how these functions impact cancer progression, survival, and response to chemotherapeutics.read more
Citations
More filters
DissertationDOI
The role of transmembrane mucin protein MUC1 in anoikis and in EGFR activation of human epithelial cancer cells
Book ChapterDOI
EGFR Inhibitors as Therapeutic Agents in Head and Neck Cancer
Hanqing Liu,Jennifer R. Cracchiolo,Tim N. Beck,Tim N. Beck,Ilya G. Serebriiskii,Erica A. Golemis +5 more
TL;DR: The biology of EGFR and other ErbB family members in SCCHN are discussed, the current status of the application of EG FR and Erb B inhibitors are summarized, and how these therapeutic agents work is summarized.
Dissertation
Investigating breast cancer metastasis to brain in pre-clinical mouse models of metastasis
TL;DR: In this article, the authors propose a method to solve the problem of the problem: this article... ]..,.. )].. [1].
Book ChapterDOI
Major Signaling Pathways Involved in Breast Cancer
Saba Wasim Aziz,Moammir H. Aziz +1 more
TL;DR: The aim of this book chapter is to give a broad overview of signal transduction networks such as Ras/Raf/MEK/ERK and the PI3K/AKT pathways that are controlled by the EGFR superfamily of receptors.
Journal ArticleDOI
Prognostic value of localization of epidermal growth factor receptor in lung adenocarcinoma.
Jinn Li Wang,Chia Lang Fang,Yu Tien Tzeng,Han Lin Hsu,Sey En Lin,Ming Chih Yu,Kuan Jen Bai,Liang Shun Wang,Hsingjin Eugene Liu +8 more
TL;DR: EGFR proteins at different cellular locations in lung adenocarcinoma might influence the biology of cancer cells and are an independent indicator of more favorable prognosis and treatment response.
References
More filters
Journal ArticleDOI
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
Therese Sørlie,Charles M. Perou,Robert Tibshirani,Turid Aas,Stephanie Geisler,Hilde Johnsen,Trevor Hastie,Michael B. Eisen,Matt van de Rijn,Stefanie S. Jeffrey,T. Thorsen,Hanne Quist,John C. Matese,Patrick O. Brown,David Botstein,Per Eystein Lønning,Anne Lise Børresen-Dale +16 more
TL;DR: Survival analyses on a subcohort of patients with locally advanced breast cancer uniformly treated in a prospective study showed significantly different outcomes for the patients belonging to the various groups, including a poor prognosis for the basal-like subtype and a significant difference in outcome for the two estrogen receptor-positive groups.
Journal ArticleDOI
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
Axel Ullrich,Lisa M. Coussens,Joel S. Hayflick,Thomas J. Dull,Alane M. Gray,A W Tam,Jeffrey E. Lee,Yosef Yarden,Towia A. Libermann,Joseph Schlessinger +9 more
TL;DR: The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) receptor precursor, deduced from cDNA clones derived from placental and A431 carcinoma cells, reveals close similarity between the entire predicted ν-erb-B mRNA oncogene product and the receptor transmembrane and cytoplasmic domains.
Journal ArticleDOI
Immunohistochemical and Clinical Characterization of the Basal-Like Subtype of Invasive Breast Carcinoma
Torsten O. Nielsen,Forrest D. Hsu,Kristin C. Jensen,Maggie C.U. Cheang,Gamze Karaca,Zhiyuan Hu,Tina Hernandez-Boussard,Chad A. Livasy,Dave Cowan,Lynn G. Dressler,Lars A. Akslen,Joseph Ragaz,Allen M. Gown,C. Blake Gilks,Matt van de Rijn,Charles M. Perou +15 more
TL;DR: A panel of four antibodies (ER, HER1, HER2, and cytokeratin 5/6) can accurately identify basal-like tumors using standard available clinical tools and shows high specificity.
Journal ArticleDOI
Isolation of a Mouse Submaxillary Gland Protein Accelerating Incisor Eruption and Eyelid Opening in the New-born Animal
TL;DR: The isolation of the factor responsible for the earlier development of the incisors and eyelids is reported here, a heat-stable, nondialysable, antigenic protein, whose most distinctive chemical characteristic is the absence of phenylalanine and lysine.
Journal ArticleDOI
Nuclear localization of EGF receptor and its potential new role as a transcription factor
Shiaw Yih Lin,Keishi Makino,Weiya Xia,Angabin Matin,Yong Wen,Ka Yin Kwong,Lilly Y.W. Bourguignon,Mien Chie Hung +7 more
TL;DR: It is demonstrated that nuclear EGFR is strongly correlated with highly proliferating activities of tissues and associated with promoter region of cyclin D1 in vivo, suggesting that EGFR might function as a transcription factor to activate genes required for highly proliferationating activities.