The quest for genetic determinants of human longevity: challenges and insights
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TLDR
Large-scale linkage studies of long-lived families, longitudinal candidate-gene association studies and the development of analytical methods provide the potential for future progress in human studies of longevity.Abstract:
Twin studies show that genetic differences account for about a quarter of the variance in adult human lifespan. Common polymorphisms that have a modest effect on lifespan have been identified in one gene, APOE, providing hope that other genetic determinants can be uncovered. However, although variants with substantial beneficial effects have been proposed to exist and several candidates have been put forward, their effects have yet to be confirmed. Human studies of longevity face numerous theoretical and logistical challenges, as the determinants of lifespan are extraordinarily complex. However, large-scale linkage studies of long-lived families, longitudinal candidate-gene association studies and the development of analytical methods provide the potential for future progress.read more
Citations
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Epidemiological, genetic and epigenetic aspects of the research on healthy ageing and longevity.
TL;DR: The role of epidemiological, genetic and epigenetic factors in the variation of quality of ageing and lifespan, including the most promising candidate genes investigated so far are discussed, plus the methodologies applied for their identification.
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Clustering by genetic ancestry using genome-wide SNP data
Nadia Solovieff,Stephen W. Hartley,Clinton T. Baldwin,Thomas T. Perls,Martin H. Steinberg,Paola Sebastiani +5 more
TL;DR: A novel algorithm to cluster individuals into groups with similar ancestral backgrounds based on the principal components computed by PCA is developed and it is shown that matching cases and controls using the clusters assigned by the algorithm substantially reduces population stratification bias.
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Exceptional Human Longevity.
TL;DR: Overall, the aggregate literature supports that the basis for exceptional longevity is multifactorial and involves disparate combinations of genes, environment, resiliency, and chance, all of which are influenced by culture and geography.
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The ApoE gene is related with exceptional longevity: a systematic review and meta-analysis
Nuria Garatachea,Pedro J. Marín,Alejandro Santos-Lozano,Fabian Sanchis-Gomar,Enzo Emanuele,Alejandro Lucia +5 more
TL;DR: The main result for all ethnic groups combined was that the likelihood of reaching EL was negative associated with e4 allele carriage, and the association of ApoE with exceptional longevity (EL) was determined.
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Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS)
Hui Shi,Olivia Belbin,Christopher Medway,Kristelle Brown,Noor Kalsheker,Minerva M. Carrasquillo,Petroula Proitsi,John Powell,Simon Lovestone,Alison Goate,Steven G. Younkin,Peter Passmore,Kevin Morgan +12 more
TL;DR: In this article, the 10 most promising late-onset Alzheimer's disease (LOAD) susceptibility genes identified through several recent large genome-wide association studies (GWAS) were selected.
References
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