The quest for genetic determinants of human longevity: challenges and insights
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TLDR
Large-scale linkage studies of long-lived families, longitudinal candidate-gene association studies and the development of analytical methods provide the potential for future progress in human studies of longevity.Abstract:
Twin studies show that genetic differences account for about a quarter of the variance in adult human lifespan. Common polymorphisms that have a modest effect on lifespan have been identified in one gene, APOE, providing hope that other genetic determinants can be uncovered. However, although variants with substantial beneficial effects have been proposed to exist and several candidates have been put forward, their effects have yet to be confirmed. Human studies of longevity face numerous theoretical and logistical challenges, as the determinants of lifespan are extraordinarily complex. However, large-scale linkage studies of long-lived families, longitudinal candidate-gene association studies and the development of analytical methods provide the potential for future progress.read more
Citations
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Journal ArticleDOI
Personality Profile of the Children of Long-Lived Parents
TL;DR: Male offspring of long-lived fathers and mothers were more likely to be open to new experiences and be more extroverted compared with male offspring of short-livedFathers or mothers and the female offspring personality traits were unchanged.
Determinants of general health status and specific diseases of elderly women and men: A longitudinal analysis for Western and Eastern Germany
Christian Wegner,Marc Luy +1 more
TL;DR: Gender differences in health outcomes are partly explained by the higher mortality of males and the higher number of non-respondents among females, which emphasises the importance of earlier life stage intervention to reduce disease-specific risk factors.
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Screening of longevity-associated genes based on a comparison between dead and surviving populations
TL;DR: The results suggest that D2S1338-18 is associated with longevity, and this allele was found to be significantly higher in the dead group than in the survival group.
Book ChapterDOI
Profiling the Aging Cardiovascular System: Transcriptional, Proteomic, SNPs, Gene Mapping and Epigenetics Analysis
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Genetic Variation in the CYP2C Monooxygenase Enzyme Subfamily Shows No Association With Longevity in a German Population
Friederike Flachsbart,Mike Ufer,Mike Ufer,Rabea Kleindorp,Susanna Nikolaus,Stefan Schreiber,Almut Nebel +6 more
TL;DR: In this article, a comprehensive haplotype tagging approach was used to investigate whether allelic variation in the CYP2C-encoding genes was associated with human longevity, and the results suggest that there is no notable influence of sequence variations in the genes on longevity in the examined German population.
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