Journal ArticleDOI
The race for coronavirus vaccines: a graphical guide.
TLDR
Eight ways in which scientists hope to provide immunity to SARS-CoV-2 .Citations
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Journal ArticleDOI
Review of Covid-19 vaccine clinical trials - A puzzle with missing pieces.
TL;DR: A year after the initial outbreak of the Covid-19 pandemic, several Phase III clinical trials investigating vaccine safety and efficacy have been published as mentioned in this paper, including mRNA, recombinant protein, adenoviral vector and inactivated virus-based platforms.
Journal ArticleDOI
Anti-SARS-CoV-2 Spike Protein RBD Antibody Levels After Receiving a Second Dose of ChAdOx1 nCov-19 (AZD1222) Vaccine in Healthcare Workers: Lack of Association With Age, Sex, Obesity, and Adverse Reactions
Sang Won Lee,Ji-Yong Moon,Sunkyung Lee,Sunkyung Lee,Hyun Lee,SeolHwa Moon,Sung Jun Chung,Yoomi Yeo,Tai Sun Park,Dong Won Park,Tae Hyung Kim,Jang Won Sohn,Ho Joo Yoon,Sang-Heon Kim +13 more
TL;DR: In this article, the authors conducted a prospective observational study to assess the relationship of antibody level with age, sex, body mass index (BMI), and adverse reactions (ARs) to an adenovirus vector vaccine, ChAdOx1 nCoV-19.
Journal ArticleDOI
Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions.
Pranam Chatterjee,Manvitha Ponnapati,Christian Kramme,Alexandru M Plesa,Alexandru M Plesa,George M. Church,George M. Church,Joseph M. Jacobson +7 more
TL;DR: A novel computational platform for engineering peptide fusions that bind to the SARS-CoV-2 spike protein and tag it for proteasomal degradation is presented and an optimal variant in human cells is experimentally validated, showing that it inhibits production of infection-competent virus.
Journal ArticleDOI
Replicating Viral Vector-Based Vaccines for COVID-19: Potential Avenue in Vaccination Arena
TL;DR: In this article , the authors discuss the potential of replicating viral vectors as vaccine carriers for SARS-CoV-2, which is the third member of human coronavirus (CoV) that is held accountable for the current "coronavirus disease 2019 (COVID-19)" pandemic.
Journal ArticleDOI
Site mapping and small molecule blind docking reveal a possible target site on the SARS-CoV-2 main protease dimer interface.
Julia Liang,Chris Karagiannis,Eleni Pitsillou,Kevion K. Darmawan,Ken Ng,Andrew Hung,Tom C. Karagiannis,Tom C. Karagiannis +7 more
TL;DR: Small molecules, including lopinavir and ritonavir, α-ketoamide 13b, and ebselen, are investigated for their ability to interact with the main protease, and molecular dynamics simulations indicated that ligands docked both to the active site and in the dimerization region at the apex, formed relatively stable interactions.
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