Journal ArticleDOI
The role of apoptosis in cancer development and treatment response.
J. Martin Brown,Laura D. Attardi +1 more
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TLDR
This work has shown that in many tumours, apoptosis is not the main mechanism for the death of cancer cells in response to common treatment regimens, suggesting that other modes of cell death are involved in the response to therapy.Abstract:
The inactivation of programmed cell death, or apoptosis, is central to the development of cancer. This disabling of apoptotic responses might be a major contributor both to treatment resistance and to the observation that, in many tumours, apoptosis is not the main mechanism for the death of cancer cells in response to common treatment regimens. Importantly, this suggests that other modes of cell death are involved in the response to therapy.read more
Citations
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Clonogenic assay of cells in vitro
TL;DR: Clonogenic assay or colony formation assay is an in vitro cell survival assay based on the ability of a single cell to grow into a colony that can be used to determine cell reproductive death after treatment with ionizing radiation and the effectiveness of other cytotoxic agents.
Journal ArticleDOI
Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy.
TL;DR: Understanding the molecular events that regulate apoptosis in response to anticancer chemotherapy, and how cancer cells evade apoptotic death, provides novel opportunities for a more rational approach to develop molecular-targeted therapies for combating cancer.
Journal ArticleDOI
The causes and consequences of genetic heterogeneity in cancer evolution.
TL;DR: Insight is gained into the common pathways of tumour evolution that could support the development of future therapeutic strategies and shape the evolution of the cancer genome through a plethora of mechanisms.
Journal ArticleDOI
The extracellular matrix modulates the hallmarks of cancer
TL;DR: It is suggested that the success of cancer prevention and therapy programs requires an intimate understanding of the reciprocal feedback between the evolving extracellular matrix, the tumor cells and its cancer‐associated cellular stroma.
Journal ArticleDOI
Targeting cancer metabolism: a therapeutic window opens
TL;DR: Research into how changes in cell metabolism promote tumour growth has accelerated in recent years, and efforts to target metabolic dependencies of cancer cells as a selective anticancer strategy have refocused.
References
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Journal ArticleDOI
The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Journal ArticleDOI
p53, the Cellular Gatekeeper for Growth and Division
TL;DR: The author regrets the lack of citations for many important observations mentioned in the text, but their omission is made necessary by restrictions in the preparation of review manuscripts.
Journal ArticleDOI
Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands
TL;DR: The use of MSP is demonstrated to identify promoter region hypermethylation changes associated with transcriptional inactivation in four important tumor suppressor genes (p16, p15, E-cadherin and von Hippel-Lindau) in human cancer.
Book
Radiobiology for the radiologist
Eric J. Hall,Amato J. Giaccia +1 more
TL;DR: Radiobiology for the radiologist, Radiobiology in general, Radiology for radiologists as mentioned in this paper, Radiology in the field of radiology, radiology for radiology.
Journal ArticleDOI
Live or let die: the cell's response to p53
Karen H. Vousden,Xin Lu +1 more
TL;DR: Understanding the complex mechanisms that regulate whether or not a cell dies in response to p53 will ultimately contribute to the development of therapeutic strategies to repair the apoptotic p53 response in cancers.