The Role of Dysbiosis in Critically Ill Patients With COVID-19 and Acute Respiratory Distress Syndrome
Denise Battaglini,Chiara Robba,Andrea Fedele,Sebastian Daniel Trancǎ,Samir Giuseppe Sukkar,Vincenzo Di Pilato,Matteo Bassetti,Daniele Roberto Giacobbe,Antonio Vena,Nicolò Patroniti,Lorenzo Ball,Iole Brunetti,Antoni Torres Martí,Patricia R. M. Rocco,Paolo Pelosi +14 more
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TLDR
In this paper, the authors provide an overview of possible interaction between patients' microbiota dysbiosis and clinical status of severe acute respiratory syndrome coronavirus disease 2019 with acute respiratory distress syndrome (ARDS), taking into consideration the characteristic hyperinflammatory state of this condition, respiratory distress, and provides an overview on possible nutritional strategies for critically ill patients with COVID19-ARDS.Abstract:
In late December 2019, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) quickly spread worldwide, and the syndrome it causes, coronavirus disease 2019 (COVID-19), has reached pandemic proportions. Around 30% of patients with COVID-19 experience severe respiratory distress and are admitted to the intensive care unit for comprehensive critical care. Patients with COVID-19 often present an enhanced immune response with a hyperinflammatory state characterized by a "cytokine storm," which may reflect changes in the microbiota composition. Moreover, the evolution to acute respiratory distress syndrome (ARDS) may increase the severity of COVID-19 and related dysbiosis. During critical illness, the multitude of therapies administered, including antibiotics, sedatives, analgesics, body position, invasive mechanical ventilation, and nutritional support, may enhance the inflammatory response and alter the balance of patients' microbiota. This status of dysbiosis may lead to hyper vulnerability in patients and an inappropriate response to critical circumstances. In this context, the aim of our narrative review is to provide an overview of possible interaction between patients' microbiota dysbiosis and clinical status of severe COVID-19 with ARDS, taking into consideration the characteristic hyperinflammatory state of this condition, respiratory distress, and provide an overview on possible nutritional strategies for critically ill patients with COVID-19-ARDS.read more
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Laboratory Biomarkers for Diagnosis and Prognosis in COVID-19
Denise Battaglini,Miquéias Lopes-Pacheco,Hugo C. Castro-Faria-Neto,Paolo Pelosi,Patricia R. M. Rocco +4 more
TL;DR: A narrative review aims to identify laboratory biomarkers that have shown significant diagnostic and prognostic value for risk stratification in COVID-19 and discusses the possible clinical application of novel analytic strategies, like metabolomics and proteomics.
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Diagnostic, Prognostic, and Therapeutic Roles of Gut Microbiota in COVID-19: A Comprehensive Systematic Review
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TL;DR: A study showed a significant change of gut microbiome composition in COVID-19 patients compared with healthy individuals and proposed the gut microbiota as a potential diagnostic, prognostic, and therapeutic strategy for CO VID-19.
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Cross-talk between immune system and microbiota in COVID-19.
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TL;DR: In this article, the authors discuss the role of probiotics in restoring the balance of the gut microbiota and modulation of cytokine storm, which can help manage the mortality and morbidity rates associated with SARS-CoV-2 infection.
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COVID-19-Associated Candidiasis: Possible Patho-Mechanism, Predisposing Factors, and Prevention Strategies
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Personalized medicine using omics approaches in acute respiratory distress syndrome to identify biological phenotypes
Denise Battaglini,Lou’i Al-Husinat,Ana Gabriela Costa Normando,Adriana Franco Paes Leme,Kleber G. Franchini,Marcelo M. Morales,Paolo Pelosi,Patricia R. M. Rocco +7 more
TL;DR: In this paper , a narrative review assesses recent evidence regarding genomics, proteomics, and metabolomics in acute respiratory distress syndrome (ARDS) research, which may help differentiate between different types of damage and predict clinical outcome and risk.
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