The Third International Consensus Guidelines on the Management of Cytomegalovirus in Solid-organ Transplantation
Camille N. Kotton,Deepali Kumar,Angela M. Caliendo,Shirish Huprikar,Sunwen Chou,Lara Danziger-Isakov,Atul Humar +6 more
Reads0
Chats0
TLDR
Highlights include advances in molecular and immunologic diagnostics, improved understanding of diagnostic thresholds, optimized methods of prevention, advances in the use of novel antiviral therapies and certain immunosuppressive agents, and more savvy approaches to treatment resistant/refractory disease.Abstract:
Cytomegalovirus (CMV) remains one of the most common infections after solid organ transplantation, resulting in significant morbidity, graft loss, and occasional mortality. Management of CMV varies considerably among transplant centers. A panel of experts on CMV and solid organ transplant was convened by The Infectious Diseases Section of The Transplantation Society to develop evidence and expert opinion-based consensus guidelines on CMV management including diagnostics, immunology, prevention, treatment, drug resistance, and pediatric issues.read more
Citations
More filters
Journal ArticleDOI
Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy.
William D. Rawlinson,Suresh B. Boppana,Karen B. Fowler,David W. Kimberlin,Tiziana Lazzarotto,Sophie Alain,Kate Daly,Sara Menlove Doutre,Laura Gibson,Michelle L. Giles,Janelle Greenlee,Stuart T. Hamilton,Gail J. Demmler Harrison,Lisa Hui,Lisa Hui,Cheryl A Jones,Cheryl A Jones,Pamela Palasanthiran,Pamela Palasanthiran,Mark R. Schleiss,Antonia W. Shand,Antonia W. Shand,Wendy J. van Zuylen +22 more
TL;DR: The International Congenital Cytomegalovirus Recommendations Group (ICG) as discussed by the authors was formed in 2015 to provide recommendations for prevention, diagnosis, and treatment of CG infection.
Journal ArticleDOI
Antiviral drug resistance of human cytomegalovirus.
Nell S. Lurain,Sunwen Chou +1 more
TL;DR: The virological and clinical data pertaining to HCMV antiviral drug resistance is summarized, which shows an evolving list of confirmed resistance mutations, although differences in interpretation have led to some confusion.
Journal ArticleDOI
A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2013 Recommendations by the Infectious Diseases Society of America (IDSA) and the American Society for Microbiology (ASM)a
Ellen Jo Baron,J. Michael Miller,Melvin P. Weinstein,Sandra S. Richter,Peter H. Gilligan,Richard B. Thomson,Paul P. Bourbeau,Karen C. Carroll,Sue C. Kehl,W. Michael Dunne,W. Michael Dunne,Barbara Robinson-Dunn,Joseph D. Schwartzman,Kimberle C. Chapin,James W. Snyder,Betty A. Forbes,Robin Patel,Jon E. Rosenblatt,Bobbi S. Pritt +18 more
TL;DR: This document, developed by both laboratory and clinical experts, provides information on which tests are valuable and in which contexts, and on tests that add little or no value for diagnostic decisions.
Journal ArticleDOI
Long‐term management of the successful adult liver transplant: 2012 practice guideline by the American Association for the Study of Liver Diseases and the American Society of Transplantation
Michael R. Lucey,Norah A. Terrault,Lolu Ojo,J. Eileen Hay,James Neuberger,Emily A. Blumberg,Lewis W. Teperman +6 more
TL;DR: This research presents a novel and scalable approach to regenerative medicine that combines traditional and innovative approaches to Gastroenterology and Hepatology that have shown real-world applications in the treatment of central giant cell granuloma.
Journal ArticleDOI
Cytomegalovirus in solid organ transplant recipients-Guidelines of the American Society of Transplantation Infectious Diseases Community of Practice.
TL;DR: There is an increasing use of CMV‐specific cell‐mediated immune assays to stratify the risk ofCMV infection after solid organ transplantation, but their role in optimizing CMV prevention and treatment efforts has yet to be demonstrated.
References
More filters
Journal ArticleDOI
Prediction of Creatinine Clearance from Serum Creatinine
Donald W. Cockcroft,M H Gault +1 more
TL;DR: A formula has been developed to predict Creatinine clearance from serum creatinine (Scr) in adult males: Ccr = (140 – age) (wt kg)/72 × Scr (mg/100ml) (15% less i).
Journal ArticleDOI
GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Gordon H. Guyatt,Andrew D Oxman,Gunn Elisabeth Vist,Regina Kunz,Yngve Falck-Ytter,Pablo Alonso-Coello,Holger J. Schünemann +6 more
TL;DR: The advantages of the GRADE system are explored, which is increasingly being adopted by organisations worldwide and which is often praised for its high level of consistency.
Journal ArticleDOI
Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate.
Andrew S. Levey,Josef Coresh,Tom Greene,Lesley A. Stevens,Yaping (Lucy) Zhang,Stephen Hendriksen,John W. Kusek,Frederick Van Lente +7 more
TL;DR: The MDRD Study equation has now been reexpressed for use with a standardized serum creatinine assay, allowing GFR estimates to be reported in clinical practice by using standardized serumcreatinine and overcoming this limitation to the current use of GFR estimating equations.
Journal ArticleDOI
New Equations to Estimate GFR in Children with CKD
George J. Schwartz,Alvaro Muñoz,Michael F. Schneider,Robert H. Mak,Frederick J. Kaskel,Bradley A. Warady,Susan L. Furth +6 more
TL;DR: In a test set of 168 CKiD patients at 1 yr of follow-up, this formula compared favorably with previously published estimating equations for children, and with height measured in cm, a bedside calculation provides a good approximation to the estimated GFR formula.
Journal ArticleDOI
What is “quality of evidence” and why is it important to clinicians?
Gordon H. Guyatt,Andrew D Oxman,Regina Kunz,Gunn Elisabeth Vist,Yngve Falck-Ytter,Holger J. Schünemann +5 more
TL;DR: Guideline developers use a bewildering variety of systems to rate the quality of the evidence underlying their recommendations as mentioned in this paper, some are facile, some confused, and others sophisticated but complex.