Journal ArticleDOI
Thermodynamic binding studies of galectin-1, -3 and -7.
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TLDR
The results show important differences in the specificities of these three galectins toward poly-N-acetyllactosamine epitopes found on the surface of cells.Abstract:
The carbohydrate binding specificities of the galectin family of animal lectins has been the source of intense recent investigations. Isothermal titration microcalorimetry (ITC) provides direct determination of the thermodynamics of binding of carbohydrates to lectins, and has provided important insights into the fine carbohydrate binding specificities of a wide number of plant and animal lectins. Recent ITC studies have been performed with galectin-1, galectin-3 and galectin-7 and their interactions with sialylated and non-sialylated carbohydrates. The results show important differences in the specificities of these three galectins toward poly-N-acetyllactosamine epitopes found on the surface of cells. Published in 2004.read more
Citations
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Dissertation
Galectin-8 specificity to cells: from broad outside to fine inside
TL;DR: This thesis is aimed at investigating the fine specificity of the two carbohydrate recognition domains of a human lectin, galectin-8, and to relate this fine specificity with cell surface binding and induced cellular effects.
Book ChapterDOI
Galectin-1: Forms and Functions
TL;DR: Gal-1 is a promising molecular target for the development of new and original therapeutic tools for some kinds of inflammation-related diseases, neurodegenerative pathologies and muscular dystrophies and the targeted inhibition of Gal-1 expression is what should be developed for therapeutic applications against cancer progression.
References
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Journal ArticleDOI
A model for p53-induced apoptosis
Kornelia Polyak,Kornelia Polyak,Yong Xia,Jay L. Zweier,Kenneth W. Kinzler,Bert Vogelstein,Bert Vogelstein +6 more
TL;DR: Examination of transcripts induced by p53 expression before the onset of apoptosis stimulated additional biochemical and pharmacological experiments suggesting that p53 results in apoptosis through a three-step process: the transcriptional induction of redox-related genes; the formation of reactive oxygen species; and the oxidative degradation of mitochondrial components, culminating in cell death.
Journal ArticleDOI
Galectins. Structure and function of a large family of animal lectins.
Journal ArticleDOI
Galectins: A Family of Animal Lectins That Decipher Glycocodes
Ken-ichi Kasai,Jun Hirabayashi +1 more
TL;DR: Crystallographic studies revealed that galectins and legume lectins such as concanavalin A have a common topology in spite of the absence of sequence homology, which suggests a possible relationship between animal and plant lectins, and the existence of a lectin super family.
Journal ArticleDOI
X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution.
Jayaraman Seetharaman,Amit Kanigsberg,Rita Slaaby,Hakon Leffler,Samuel H. Barondes,James M. Rini +5 more
TL;DR: The x-ray crystal structure of the human galectin-3 CRD, in complex with lactose and N-acetyllactosamine, at 2.1-A resolution was reported in this paper.
Journal Article
Restricted Receptor Segregation into Membrane Microdomains Occurs on Human T Cells During Apoptosis Induced by Galectin-1
TL;DR: It is determined that galectin-1 binds to a restricted set of T cell surface glycoproteins, and that only CD45, CD43, and CD7 appear to directly participate in galectIn-1-induced apoptosis.