Thirdhand cigarette smoke leads to age‐dependent and persistent alterations in the cecal microbiome of mice
Li He,Li He,Yan-Xia Zhou,Yan-Xia Zhou,Yuqing Zhang,Yuqing Zhang,Bo Hang,Hang Chang,Suzaynn F. Schick,Susan E. Celniker,Yankai Xia,Antoine M. Snijders,Jian-Hua Mao +12 more
- Vol. 10, Iss: 3
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In this article, the effect of thirdhand cigarette smoke exposure and exposure age on the gut microbiome diversity was investigated in C57BL/6 mice, which were exposed to THS at human exposure relevant levels for three weeks during three different life stages: postnatal, pubescent and adult.Abstract:
The gut microbiome composition is influenced by many factors including environmental exposures. Here, we investigated the effect of thirdhand cigarette smoke (THS) and exposure age on gut microbiome diversity. C57BL/6 mice were exposed to THS at human exposure relevant levels for three weeks during three different life stages: postnatal (0-3 weeks of age), pubescent (4-7 weeks of age), and adult (9-12 weeks of age), respectively. Cecal microbiome profiles were assessed at 17 weeks of age by 16S rRNA gene sequencing. We found that age at THS exposure strongly influenced the cecal microbiome composition. Although postnatal THS exposure significantly influenced the microbial composition, pubescent and adulthood exposures only had minor effects. The microbiome of postnatally THS-exposed mice significantly increased several degradation pathways that regulate glycolysis and pyruvate decarboxylation, and significantly decreased coenzyme A biosynthesis and pyrimidine deoxyribonucleoside salvage. Our results indicate that mouse postnatal development is particularly susceptible to persistent THS exposure effects on the gut microbiome.read more
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TL;DR: The pace of progress in reducing smoking prevalence has been heterogeneous across geographies, development status, and sex, and as highlighted by more recent trends, maintaining past rates of decline should not be taken for granted, especially in women and in low- SDI to middle-SDI countries.
Journal ArticleDOI
Thirdhand Tobacco Smoke: Emerging Evidence and Arguments for a Multidisciplinary Research Agenda
Georg E. Matt,Penelope J.E. Quintana,Hugo Destaillats,Lara A. Gundel,Mohamad Sleiman,Brett C. Singer,Peyton Jacob,Neal L. Benowitz,Jonathan P. Winickoff,Virender K. Rehan,Prue Talbot,Suzaynn F. Schick,Jonathan M. Samet,Yinsheng Wang,Bo Hang,Manuela Martins-Green,James F. Pankow,Melbourne F. Hovell +17 more
TL;DR: The existing evidence on thirdhand smoke (THS) provides strong support for pursuing a programmatic research agenda to close gaps in current understanding of the chemistry, exposure, toxicology, and health effects of THS, as well as its behavioral, economic, and sociocultural considerations and consequences.