Journal ArticleDOI
Three new indole alkaloids from Trigonostemon lii.
Cheng-Jian Tan,Ying-Tong Di,Yue-Hu Wang,Yu Zhang,Yi-Kang Si,Qiang Zhang,Suo Gao,Xu-Jia Hu,Xin Fang,Shi-Fei Li,Xiao-Jiang Hao +10 more
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TLDR
Three unprecedented indole alkaloids, trigonoliimines A-C (1-3) with a unique polycyclic system, were isolated from the leaves of Trigonostemon lii Y. T. Chang.About:
This article is published in Organic Letters.The article was published on 2010-04-21. It has received 115 citations till now. The article focuses on the topics: Trigonostemon & Indole test.read more
Citations
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Gold catalysis in total synthesis – recent achievements
TL;DR: The applications of gold catalysed reactions in total synthesis during the years since the last article are reviewed and literature analysis is conducted to evaluate the progress in this field.
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A review on recent developments of indole-containing antiviral agents.
TL;DR: This review focused on the recent development of indole derivatives as antiviral agents and summarized the structure property, hoping to inspire new and even more creative approaches to discover novel drugs with different modes of action.
Journal ArticleDOI
Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view.
Navriti Chadha,Om Silakari +1 more
TL;DR: An overview of the chemistry, biology, and toxicology of indoles focusing on their application as drugs is provided to corroborate the information available on the natural indole alkaloids, indole based FDA approved drugs and clinical trial candidates having diverse therapeutic implementations.
Journal ArticleDOI
Enantioselective Arylative Dearomatization of Indoles via Pd-Catalyzed Intramolecular Reductive Heck Reactions
TL;DR: A highly enantioselective intramolecular arylative dearomatization of indoles via palladium-catalyzed reductive Heck reactions was developed and led to a series of optically active indolines bearing C2-quaternary stereocenters in modest to good yields with excellent enantiOSElectivities.
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Enantioselective Synthesis of Indole-Annulated Medium-Sized Rings
Lin Huang,Li-Xin Dai,Shu-Li You +2 more
TL;DR: Asymmetric synthesis of indole-annulated medium-sized-ring compounds is developed through an iridium-catalyzed allylic dearomatization/retro-Mannich/hydrolysis cascade reaction.
References
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Journal ArticleDOI
Calculation of Optical Rotation Using Density Functional Theory
TL;DR: In this article, Hartree et al. used ab initio density functional theory (DFT) to calculate the frequency-dependent electric dipole−magnetic dipole polarizability tensor, βαβ(ν), for 30 rigid chiral molecules.
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Hartree−Fock and Density Functional Theory ab Initio Calculation of Optical Rotation Using GIAOs: Basis Set Dependence
TL;DR: In this article, Hartree−Fock (HF) and density functional theory (DFT) calculations of the electric dipole−magnetic dipole polarizability βαβ are reported for the chiral molecules methyloxirane (1) and tr...
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Site-directed PEGylation of trichosanthin retained its anti-HIV activity with reduced potency in vitro.
Jian-Hua Wang,Siu-Cheung Tam,Hai Huang,Dong-Yun Ouyang,Dong-Yun Ouyang,Yuan-Yuan Wang,Yuan-Yuan Wang,Yong-Tang Zheng +7 more
TL;DR: The in vitro study showed that the anti-HIV activity of PEGylated TCS was retained with reduced potency, and the in vivo activity is expected to have only slightly changed due to other beneficial effects like prolonged half-life.
Journal ArticleDOI
Determination of the absolute configurations of natural products using TDDFT optical rotation calculations: the iridoid oruwacin.
TL;DR: The results show that the assignment of the AC of a natural product by comparison of its [alpha] D to that of a chemically related molecule can be unreliable and should not be assumed to be definitive.
Journal ArticleDOI
Lotthanongine, an unprecedented flavonoidal indole alkaloid from the roots of Thai medicinal plant, Trigonostemon reidioides
Tripetch Kanchanapoom,Tripetch Kanchanapoom,Ryoji Kasai,Phannipha Chumsri,Krisana Kraisintu,Kazuo Yamasaki +5 more
TL;DR: Lotthanongine, a novel flavonoidal indole alkaloid, was isolated from the roots of Trigonostemon reidioides (Euphorbiaceae) together with afzelechin-(4α→8)-afzelechine as mentioned in this paper.
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Concise Total Synthesis and Stereochemical Revision of all (―)-Trigonoliimines
Sunkyu Han,Mohammad Movassaghi +1 more