Book ChapterDOI
Tissue Interactions Regulating Tooth Development and Renewal.
Anamaria Balic,Irma Thesleff +1 more
TLDR
The principles and molecular mechanisms of the epithelial-mesenchymal interactions regulating successive stages of tooth formation are described, with special reference to the shift of tooth-forming potential from epithelium to mesenchyme.Abstract:
Reciprocal interactions between epithelial and mesenchymal tissues play a fundamental role in the morphogenesis of teeth and regulate all aspects of tooth development. Extensive studies on mouse tooth development over the past 25 years have uncovered the molecular details of the signaling networks mediating these interactions (reviewed by Jussila & Thesleff, 2012; Lan, Jia, & Jiang, 2014). Five conserved signaling pathways, namely, the Wnt, BMP, FGF, Shh, and Eda, are involved in the mediation of the successive reciprocal epithelial-mesenchymal cross talk which follows the general principle of morphogenetic interactions (Davidson, 1993). The pathways regulate the expression of transcription factors which confer the identity of dental epithelium and mesenchyme. The signals and transcription factors are integrated in complex signaling networks whose fine-tuning allows the generation of the variation in tooth morphologies. In this review, we describe the principles and molecular mechanisms of the epithelial-mesenchymal interactions regulating successive stages of tooth formation: (i) the initiation of tooth development, with special reference to the shift of tooth-forming potential from epithelium to mesenchyme; (ii) the morphogenesis of the tooth crown, focusing on the roles of epithelial signaling centers; (iii) the differentiation of odontoblasts and ameloblasts, which produce dentin and enamel, respectively; and (iv) the maintenance of dental stem cells, which support the continuous growth of teeth.read more
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Journal ArticleDOI
Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth.
Jan Krivanek,Jan Krivanek,Ruslan A. Soldatov,Maria Eleni Kastriti,Maria Eleni Kastriti,Tatiana Chontorotzea,Anna Nele Herdina,Julian Petersen,Julian Petersen,Bara Szarowska,Marie Landova,Veronika Kovar Matejova,Lydie Izakovičová Hollá,Ulrike Kuchler,Ivana Vidovic Zdrilic,Anushree Vijaykumar,Anamaria Balic,Pauline Marangoni,Ophir D. Klein,Vitor C. M. Neves,Val Yianni,Paul T. Sharpe,Tibor Harkany,Tibor Harkany,Brian D. Metscher,Marc Bajénoff,Mina Mina,Kaj Fried,Peter V. Kharchenko,Igor Adameyko,Igor Adameyko +30 more
TL;DR: An unappreciated cellular complexity of the continuously-growing mouse incisor is reported, which suggests a coherent model of cell dynamics enabling unarrested growth and an atlas of human and mouse teeth with a focus on growth and differentiation.
Journal ArticleDOI
Gli1+ Periodontium Stem Cells Are Regulated by Osteocytes and Occlusal Force.
Yi Men,Yi Men,Yuhong Wang,Yuhong Wang,Yating Yi,Dian Jing,Wenjing Luo,Bo Shen,William V. Stenberg,Yang Chai,Woo Ping Ge,Jian Q. Feng,Hu Zhao +12 more
TL;DR: Gli1+ cells in adult mouse molar PDL are identified as multi-potential stem cells giving rise to PDL, alveolar bone, and cementum, and Physiological occlusal force indirectly regulates PDLSCs activities by fine-tuning this feedback loop.
Journal ArticleDOI
Wnt Signaling in Renal Cell Carcinoma
TL;DR: The current status quo regarding recent research on RCC focusing on the involvement of the Wnt/β-catenin pathway is summarized and its understanding could facilitate the identification of potential therapeutic targets, new drugs and diagnostic biomarkers.
Journal ArticleDOI
The Biology Underlying Abnormalities of Tooth Number in Humans
Emma Juuri,Anamaria Balic +1 more
TL;DR: Current knowledge on the development of the primary and successional teeth in animal models is summarized and some of the common tooth abnormalities in humans are described.
Journal ArticleDOI
Mesenchymal Wnt/β-catenin signaling limits tooth number.
Elina Järvinen,Elina Järvinen,Junko Shimomura-Kuroki,Junko Shimomura-Kuroki,Anamaria Balic,Maria Jussila,Irma Thesleff +6 more
TL;DR: Using mouse models to investigate serial tooth formation reveals that contrasting changes in tooth number associated with human mutations in AXIN2 and RUNX2 result from modulation of Wnt/β-catenin signaling in dental mesenchyme.
References
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Journal ArticleDOI
Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo.
TL;DR: The mouse Hedgehog gene family consists of three members, Sonic, Desert, and Indian hedgehog (Shh, Dhh, and Ihh, respectively), relatives of the Drosophila segment polarity gene, hedgehog as mentioned in this paper.
Journal ArticleDOI
Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications
Toshiro Sato,Hans Clevers +1 more
TL;DR: The mechanisms that support this notable example of self-organization are reviewed and applications of this technology for stem cell research, disease modeling, and regenerative medicine are discussed.
Journal ArticleDOI
Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development
TL;DR: Findings support the hypothesis that BMP-4 mediates epithelial-mesenchymal interactions during early tooth development.
Journal ArticleDOI
Sonic hedgehog regulates growth and morphogenesis of the tooth
TL;DR: The role of Shh is addressed in the developing tooth in mouse by using a conditional allele to remove Shh activity shortly after ingrowth of the dental epithelium and demonstrating that Shh regulates growth and determines the shape of the tooth.
Journal ArticleDOI
Epithelial-mesenchymal signalling regulating tooth morphogenesis.
TL;DR: Interactions between the ectoderm and underlying mesenchyme constitute a central mechanism regulating the morphogenesis of teeth in vertebrate embryos.
Related Papers (5)
Tooth shape formation and tooth renewal: evolving with the same signals
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