Titanium dioxide nanoparticles exacerbate DSS-induced colitis: role of the NLRP3 inflammasome
Pedro A. Ruiz,Belén Morón,Helen M. Becker,Silvia Lang,Kirstin Atrott,Marianne R. Spalinger,Michael Scharl,Kacper A. Wojtal,Anne Fischbeck-Terhalle,Isabelle Frey-Wagner,Martin Hausmann,Thomas Kraemer,Gerhard Rogler +12 more
Reads0
Chats0
TLDR
Findings indicate that individuals with a defective intestinal barrier function and pre-existing inflammatory condition, such as IBD, might be negatively impacted by the use of TiO2 nanoparticles.Abstract:
Objective Western lifestyle and diet are major environmental factors playing a role in the development of IBD. Titanium dioxide (TiO 2 ) nanoparticles are widely used as food additives or in pharmaceutical formulations and are consumed by millions of people on a daily basis. We investigated the effects of TiO 2 in the development of colitis and the role of the nucleotide-binding oligomerisation domain receptor, pyrin domain containing (NLRP)3 inflammasome. Design Wild-type and NLRP3-deficient mice with dextran sodium sulfate-induced colitis were orally administered with TiO 2 nanoparticles. The proinflammatory effects of TiO 2 particles in cultured human intestinal epithelial cells (IECs) and macrophages were also studied, as well as the ability of TiO 2 crystals to traverse IEC monolayers and accumulate in the blood of patients with IBD using inductively coupled plasma mass spectrometry. Results Oral administration of TiO 2 nanoparticles worsened acute colitis through a mechanism involving the NLRP3 inflammasome. Importantly, crystals were found to accumulate in spleen of TiO 2 -administered mice. In vitro, TiO 2 particles were taken up by IECs and macrophages and triggered NLRP3-ASC-caspase-1 assembly, caspase-1 cleavage and the release of NLRP3-associated interleukin (IL)-1β and IL-18. TiO 2 also induced reactive oxygen species generation and increased epithelial permeability in IEC monolayers. Increased levels of titanium were found in blood of patients with UC having active disease. Conclusion These findings indicate that individuals with a defective intestinal barrier function and pre-existing inflammatory condition, such as IBD, might be negatively impacted by the use of TiO 2 nanoparticles.read more
Citations
More filters
Book ChapterDOI
Synthesis of Metallic and Metal Oxide Particles
Kateryna Loza,Matthias Epple +1 more
TL;DR: In this article, the authors present an overview of the preparation of metallic and metal oxide nanoparticles by bottom-up and top-down approaches, and describe basic synthetic routes for prominent cases of metals (gold, silver, platinum and copper) and metal oxides (zinc oxide, titania, and silica).
Journal ArticleDOI
TSPO Deficiency Exacerbates GSDMD-Mediated Macrophage Pyroptosis in Inflammatory Bowel Disease
Xue Zhang,Jingyi Han,Yi Xu,Meng-shen Cai,Fei Gao,Jiajia Han,Dongdong Wang,Yi Fu,Hui-zhen Chen,Wei He,Jianmin Zhang +10 more
TL;DR: In response to inflammatory injury, TSPO expression is rapidly upregulated and provides a protective function against GSDMD-mediated pyroptosis, which helps to better understand the biological role of T SPO and a novel regulatory mechanism of the pyroPTosis process.
DissertationDOI
A distinct pattern of sterile inflammation induced by zinc oxide nanowires.
TL;DR: In this article, the authors present a list of FIGURE FIGURES and Table of FIGURES for the first time. But they do not specify the order of the FIGURES.
Journal ArticleDOI
Intestinal Microecology of Mice Exposed to TiO2 Nanoparticles and Bisphenol A
TL;DR: This study is the first to reveal the combined effects of TiO2 NPs and BPA on the mammalian gut microbial community and metabolism dynamics, which is of great value to human health.
Journal ArticleDOI
Ginsenoside Rb1 exerts therapeutic effects on ulcerative colitis through regulating the Nrf2/PIP2/NLRP3 inflammasome signaling pathway
Siyuan Li,Renyikun Yuan,Qiumei Fan,Chun-Dong Zhang,Shan-Shu Han,Jilang Li,Zhipeng Xu,Kaili Sun,Qiongming Xu,Chun Yao,Shilin Yang,Hong Ni Gao +11 more
TL;DR: Wang et al. as mentioned in this paper explored the effects and potential mechanisms of ginsenoside rb1 on UC and showed that GRb1 has therapeutic effects on UC in vitro and in vivo through regulating the Nrf2/PIP2/NLRP3 pathway.
References
More filters
Journal ArticleDOI
Gout-associated uric acid crystals activate the NALP3 inflammasome
TL;DR: It is shown that MSU and CPPD engage the caspase-1-activating NALP3 (also called cryopyrin) inflammasome, resulting in the production of active interleukin (IL)-1β and IL-18 in mice deficient in the IL-1β receptor.
Journal ArticleDOI
Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences
TL;DR: Differences in incidence across age, time, and geographic region suggest that environmental factors significantly modify the expression of Crohn's disease and ulcerative colitis.
Journal ArticleDOI
Cryopyrin activates the inflammasome in response to toxins and ATP
Sanjeev Mariathasan,David S. Weiss,Kim Newton,Jacqueline McBride,Karen O'Rourke,Meron Roose-Girma,Wyne P. Lee,Yvette Weinrauch,Denise M. Monack,Vishva M. Dixit +9 more
TL;DR: It is shown that cryopyrin-deficient macrophages cannot activate caspase-1 in response to Toll-like receptor agonists plus ATP, the latter activating the P2X7 receptor to decrease intracellular K+ levels.
Journal ArticleDOI
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
Veit Hornung,Franz Bauernfeind,Annett Halle,Eivind O. Samstad,Eivind O. Samstad,Hajime Kono,Kenneth L. Rock,Katherine A. Fitzgerald,Eicke Latz,Eicke Latz +9 more
TL;DR: It is demonstrated that silica and aluminum salt crystals activated inflammasomes formed by the cytoplasmic receptor NALP3, which senses lysosomal damage as an endogenous 'danger' signal.
Related Papers (5)
Food-grade TiO 2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon.
Sarah Bettini,Elisa Boutet-Robinet,Christel Cartier,Christine Coméra,Eric Gaultier,J. Dupuy,Nathalie Naud,Sylviane Taché,Patrick Grysan,Solenn Reguer,Nathalie Thieriet,Matthieu Réfrégiers,Dominique Thiaudière,Jean Pierre Cravedi,Marie Carrière,Jean-Nicolas Audinot,Fabrice Pierre,Laurence Guzylack-Piriou,Eric Houdeau +18 more