Titanium nanostructures for biomedical applications
Mukta Kulkarni,Anca Mazare,Ekaterina Gongadze,Šárka Perutková,Veronika Kralj-Iglič,Ingrid Milošev,Patrik Schmuki,Aleš Iglič,Miran Mozetič +8 more
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TLDR
Perhaps the most spectacular and surprising one-dimensional structures and their unique biomedical applications for increased osseointegration, protein interaction and antibacterial properties are focused on.Abstract:
Titanium and titanium alloys exhibit a unique combination of strength and biocompatibility, which enables their use in medical applications and accounts for their extensive use as implant materials in the last 50 years. Currently, a large amount of research is being carried out in order to determine the optimal surface topography for use in bioapplications, and thus the emphasis is on nanotechnology for biomedical applications. It was recently shown that titanium implants with rough surface topography and free energy increase osteoblast adhesion, maturation and subsequent bone formation. Furthermore, the adhesion of different cell lines to the surface of titanium implants is influenced by the surface characteristics of titanium; namely topography, charge distribution and chemistry. The present review article focuses on the specific nanotopography of titanium, i.e. titanium dioxide (TiO2) nanotubes, using a simple electrochemical anodisation method of the metallic substrate and other processes such as the hydrothermal or sol-gel template. One key advantage of using TiO2 nanotubes in cell interactions is based on the fact that TiO2 nanotube morphology is correlated with cell adhesion, spreading, growth and differentiation of mesenchymal stem cells, which were shown to be maximally induced on smaller diameter nanotubes (15 nm), but hindered on larger diameter (100 nm) tubes, leading to cell death and apoptosis. Research has supported the significance of nanotopography (TiO2 nanotube diameter) in cell adhesion and cell growth, and suggests that the mechanics of focal adhesion formation are similar among different cell types. As such, the present review will focus on perhaps the most spectacular and surprising one-dimensional structures and their unique biomedical applications for increased osseointegration, protein interaction and antibacterial properties.read more
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Regulation of RAW 264.7 macrophages behavior on anodic TiO 2 nanotubular arrays
TL;DR: In this article, the behavior of RAW264.7 macrophages on TiO2 nanotubular arrays with a wide range diameter (from 20 to 120 nm) fabricated by an electrochemical anodization process was evaluated by CCK-8, live/dead staining and ELISA.
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Molecular-Level Interactions between Engineered Materials and Cells.
TL;DR: This finding suggests that better molecular-level understanding of the interactions between cells and materials may guide the design and construction of sophisticated artificial substrates, potentially enabling control of cells for use in various biomedical applications.
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Annealing Temperature Effect on Tribocorrosion and Biocompatibility Properties of TiO2 Nanotubes
Ana C. C. Almeida Fontes,Ana C. C. Almeida Fontes,Luciane Sopchenski,Luciane Sopchenski,Carlos Augusto Henning Laurindo,Ricardo D. Torres,Ketul C. Popat,Paulo Soares +7 more
TL;DR: In this article, the influence of the annealing treatment on the microstructure and mechanical properties of a TiO2 nanotube layer produced on titanium, and consequently, on the tribocorrosive resistance, and the biological response to human dermal fibroblasts (HDF).
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Effect of microstructure on the nanotube growth by anodic oxidation on Ti-10Nb alloy
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A highly sensitive x-ray imaging modality for hepatocellular carcinoma detection in vitro.
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